Borderline personality disorder: Difference between revisions

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The [[Chinese Society of Psychiatry]]'s [[CCMD]] has a comparable diagnosis of Impulsive Personality Disorder. A patient diagnosed as having IPD must display "affective outbursts" and "marked impulsive behavior", plus at least three out of eight other symptoms. The construct has been described as a hybrid of the impulsive and borderline subtypes of the ICD's Emotionally Unstable Personality Disorder, and also incorporates six of the nine DSM BPD criteria.<ref>Zhong, J.; F. Leung ([[2007-01-05]]). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17254494 Should borderline personality disorder be included in the fourth edition of the Chinese classification of mental disorders?]" ''Chin Med J'' (English) '''120''' (1): 77-82. Retrieved on [[2007-09-21]].</ref>
The [[Chinese Society of Psychiatry]]'s [[CCMD]] has a comparable diagnosis of Impulsive Personality Disorder. A patient diagnosed as having IPD must display "affective outbursts" and "marked impulsive behavior", plus at least three out of eight other symptoms. The construct has been described as a hybrid of the impulsive and borderline subtypes of the ICD's Emotionally Unstable Personality Disorder, and also incorporates six of the nine DSM BPD criteria.<ref>Zhong, J.; F. Leung ([[2007-01-05]]). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17254494 Should borderline personality disorder be included in the fourth edition of the Chinese classification of mental disorders?]" ''Chin Med J'' (English) '''120''' (1): 77-82. Retrieved on [[2007-09-21]].</ref>
===Aspects of BPD===
It has been noted that there is probably no other mental disorder about which so many articles and books have been written, yet about which so little is known based on empirical research.<ref name="cogemo">Arntz, A. (September 2005). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16018875 Introduction to special issue: cognition and emotion in borderline personality disorder.]" ''J Behav Ther Exp Psychiatry'' '''36''' (3): 167-72. Retrieved on [[2007-09-21]].</ref>
Studies suggest that individuals with BPD tend to experience frequent, strong and long-lasting states of [[aversives|aversive]] tension, often triggered by perceived rejection, being alone, or perceived failure.<ref>Stiglmayr, C.E.; T. Grathwol, M.M. Leneham, et al. (May 2005). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=1581973 Aversive tension in patients with borderline personality disorder: a computer-based controlled field study.]" ''Acta Psychiatr Scand'' '''111''' (5): 372-9. Retrieved on [[2007-09-21]].</ref> Individuals with BPD may show [[lability]] (changeability) between anger and anxiety or between depression and anxiety<ref>Koenigsberg H.W.; P.D. Harvey, V. Mitropoulou, et al. (May 2002). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=11986132 Characterizing affective instability in borderline personality disorder]". ''Am J Psychiatry'' '''159''' (5): 784-8. Retrieved on [[2007-09-21]].</ref> and temperamental sensitivity to emotive stimuli.<ref>Meyer, B.; M. Ajchenbrenner, D.P. Bowles (December 2005). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16553560 Sensory sensitivity, attachment experiences, and rejection responses among adults with borderline and avoidant features]". ''J Personal Disord'' '''19''' (6): 641-58. Retrieved on [[2007-09-21]].</ref>
The negative emotional states particularly associated with BPD have been grouped into four categories: extreme feelings in general; feelings of destructiveness or self-destructiveness; feelings of fragmentation or lack of identity; and feelings of victimization.<ref>Zanarini, M.C.; F.R. Frankenburg, C.J. DeLuca, et al. (1998). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10370445 The pain of being borderline: dysphoric states specific to borderline personality disorder]". ''Harvard Review of Psychiatry'' '''6''' (4): 201-7. Retrieved on [[2007-09-21]].</ref>
Individuals with BPD can be very sensitive to the way others treat them, reacting strongly to perceived criticism or hurtfulness. Their feelings about others often shift from positive to negative, generally after a disappointment or perceived threat of losing someone. Self-image can also change rapidly from extremely positive to extremely negative. Impulsive behaviors are common, including alcohol or drug abuse, unsafe sex, gambling, and recklessness in general.<ref>American Psychiatric Association (2001). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11726742&dopt=Abstract Psychiatric Services]". ''Psychiatr Serv'' (52): 1569-70. Retrieved on [[2007-09-21]].</ref> Attachment studies suggest individuals with BPD, while being high in intimacy- or novelty-seeking, can be hyper-alert<ref name="cogemo"/> to signs of rejection or not being valued and tend towards insecure, ambivalent, preoccupied or fearful attitudes towards relationships.<ref>Levy, K.N.; K.B. Meehan, M. Weber, et al. (March &ndash; April 2005). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15802944 Attachment and borderline personality disorder: implications for psychotherapy]". ''Psychopathology'' '''38''' (2): 64-74. Retrieved on [[2007-09-21]].</ref> They tend to view the world generally as dangerous and malevolent, and themselves as powerless, vulnerable, unacceptable and unsure in self-identity.<ref name="cogemo"/>
Individuals with BPD are often described, including by some mental health professionals (and in the DSM-IV),<ref name="criteria"/> as deliberately manipulative or difficult, but analyses and findings generally trace behaviors to inner pain and turmoil, powerlessness and defensive reactions, or limited coping and communication skills.<ref name="manipulative">Potter, N. (April 2006). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16643118 What is manipulative behavior, anyway?]" ''J Personal Disord.'' '''20''' (2): 139-56; discussion 181-5. Retrieved on [[2007-09-21]].</ref><ref>McKay, D.; C.A. Gavigan, S. Kulchycky (2004). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=15224626 Social skills and sex-role functioning in borderline personality disorder: relationship to self-mutilating behavior]". ''Cogn Behav Ther'' '''33''' (1): 27-35. Retrieved on [[2007-09-21]].</ref><ref>Linehan, M. (1993). ''Cognitive-behavioral treatment of borderline personality disorder.'' New York: Guilford. [[Special:Booksources/0898621836|ISBN 0898621836]].</ref> There has been limited research on family members' understanding of borderline personality disorder and the extent of burden or negative emotion experienced or expressed by family members.<ref>Hoffman, P.D.; E. Buteau, J.M. Hooley, et al. (2003). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14979218 Family members' knowledge about borderline personality disorder: correspondence with their levels of depression, burden, distress, and expressed emotion]". ''Family Process'' '''42''' (4): 469-78. Retrieved on [[2007-09-21]].</ref> Parents of individuals with BPD have been reported to show co-existing extremes of over-involvement and under-involvement.<ref name="parents">Allen, D.M.; R.G. Farmer (January &ndash; February 1996). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=8770526 Family relationships of adults with borderline personality disorder]". ''Compr Psychiatry'' '''37''' (1): 43-51. Retrieved on [[2007-09-21]].</ref> BPD has been linked to somewhat increased levels of chronic stress and conflict in romantic relationships, decreased satisfaction of romantic partners, abuse, and unwanted pregnancy; these links may largely be general to personality disorder and subsyndromal problems,<ref>Daley, S.E.; D. Burge, C. Hammen (August 2000). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11016115 Borderline personality disorder symptoms as predictors of 4-year romantic relationship dysfunction in young women: addressing issues of specificity]". ''J Abnorm Psychol'' '''109''' (3): 451-60. Retrieved on [[2007-09-21]].</ref> but such issues are commonly raised in support groups and published literature for partners of individuals with BPD.
Suicidal or self-harming behavior is one of the core diagnostic criteria in DSM IV-TR, and management of and recovery from this can be complex and challenging.<ref>Hawton, K.; E. Townsend, E. Arensman, et al. (1999). "[http://www.cochrane.org/reviews/en/ab001764.html Cochrane Collaboration Psychosocial and pharmacological treatments for deliberate self harm]". ''Cochrane Database of Systematic Reviews'' (4). Art. No.: CD001764. [[DOI: 10.1002/14651858.CD001764]]. Retrieved on [[2007-09-21]].</ref> The [[suicide]] rate is approximately eight to ten percent.<ref name=bpdtoday>[http://www.borderlinepersonalitytoday.com/main/facts.htm Borderline Personality Disorder Facts]. ''BPD Today''. Retrieved on [[2007-09-21]].</ref> The most recognized form of self-injury is automutilation (cutting the self), usually of the arms, but often other areas such as the legs, chest, belly, and face. Self-injury attempts are highly common among patients and may or may not be carried out with suicidal intent.<ref>Soloff, P.H.; J.A. Lis, T. Kelly, et al. (1994). "Self-mutilation and suicidal behavior in borderline personality disorder". ''Journal of Personality Disorders'' '''8''' (4): 257-67.</ref><ref>Gardner, D.L.; R.W. Cowdry (1985). "Suicidal and parasuicidal behavior in borderline personality disorder". ''Psychiatric Clinics of North America'' '''8''' (2): 389-403.</ref> BPD is often characterized by multiple low lethality suicide attempts triggered by seemingly minor incidents, and less commonly by high lethality attempts that are attributed to impulsiveness or comorbid major depression, with interpersonal stressors appearing to be particularly common triggers.<ref>Brodsky, B.S.; S.A. Groves, M.A. Oquendo, et al. (June 2006). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16805659&query_hl=15&itool=pubmed_docsum Interpersonal precipitants and suicide attempts in borderline personality disorder]". ''Suicide Life Threat Behav'' '''36''' (3): 313-22. Retrieved on [[2007-09-21]].</ref> Ongoing family interactions and associated vulnerabilities can lead to self-destructive behavior.<ref name="parents"/> Stressful life events related to sexual abuse have been found to be a particular trigger for suicide attempts by adolescents with a BPD diagnosis.<ref>Horesh, N.; J. Sever, A. Apter (July &ndash; August 2003). "[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=abstractplus&db=pubmed&cmd=Retrieve&dopt=abstractplus&list_uids=12923705 A comparison of life events between suicidal adolescents with major depression and borderline personality disorder]". ''Compr Psychiatry'' '''44''' (4): 277-83. Retrieved on [[2007-09-21]].</ref>


===Differential diagnosis===
===Differential diagnosis===
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The relationship between bipolar disorder and borderline personality disorder has been debated.  Some hold that the latter represents a subthreshold form of affective disorder,<ref>Akiskal, H.S.; B.I. Yerevanian, G.C. Davis, et al. (1985). "The nosologic status of borderline personality: Clinical and polysomnographic study". ''Am J Psychiatry'' (142): 192-8</ref><ref>Gunderson, J.G.; G.R. Elliott (1985). "The interface between borderline personality disorder and affective disorder". ''Am J Psychiatry''. (142):277-288.</ref> while others maintain the distinctness between the disorders, noting they often co-occur.<ref>McGlashan, T.H. (1983). "The borderline syndrome: Is it a variant of schizophrenia or affective disorder?" ''Arch Gen Psychiatry''. (40): 1319-23.</ref><ref>Pope, H.G. Jr.; J.M. Jonas, J.I. Hudson, et al. (1983). "The validity of DSM-III borderline personality disorder: A phenomenologic, family history, treatment response, and long term follow up study". ''Arch Gen Psychiatry'' (40): 23-30.</ref>
The relationship between bipolar disorder and borderline personality disorder has been debated.  Some hold that the latter represents a subthreshold form of affective disorder,<ref>Akiskal, H.S.; B.I. Yerevanian, G.C. Davis, et al. (1985). "The nosologic status of borderline personality: Clinical and polysomnographic study". ''Am J Psychiatry'' (142): 192-8</ref><ref>Gunderson, J.G.; G.R. Elliott (1985). "The interface between borderline personality disorder and affective disorder". ''Am J Psychiatry''. (142):277-288.</ref> while others maintain the distinctness between the disorders, noting they often co-occur.<ref>McGlashan, T.H. (1983). "The borderline syndrome: Is it a variant of schizophrenia or affective disorder?" ''Arch Gen Psychiatry''. (40): 1319-23.</ref><ref>Pope, H.G. Jr.; J.M. Jonas, J.I. Hudson, et al. (1983). "The validity of DSM-III borderline personality disorder: A phenomenologic, family history, treatment response, and long term follow up study". ''Arch Gen Psychiatry'' (40): 23-30.</ref>


===Co-morbidity===
===Co-morbid diagnoses===
[[Co-morbid]] (co-occurring) conditions in BPD are common. When comparing individuals diagnosed with BPD to those diagnosed with other kinds of personality disorders, the former showed a higher rate of also meeting criteria for:<ref>Zanarini, M.C.; F.R. Frankenburg, E.D. Dubo, et al. (1998). "[http://ajp.psychiatryonline.org/cgi/content/full/155/12/1733 Axis I Comorbidity of Borderline Personality Disorder]". ''Am J Psychiatry''. (155): 1733-9. Retrieved on [[2007-09-23]].</ref>  
[[Co-morbid]] (co-occurring) conditions in BPD are common. When comparing individuals diagnosed with BPD to those diagnosed with other kinds of personality disorders, the former showed a higher rate of also meeting criteria for:<ref>Zanarini, M.C.; F.R. Frankenburg, E.D. Dubo, et al. (1998). "[http://ajp.psychiatryonline.org/cgi/content/full/155/12/1733 Axis I Comorbidity of Borderline Personality Disorder]". ''Am J Psychiatry''. (155): 1733-9. Retrieved on [[2007-09-23]].</ref>  


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[[Substance abuse]] is a common problem in BPD, whether due to impulsivity or as a coping mechanism, and 50% to 70% of psychiatric inpatients with BPD have been found to meet criteria for a substance use disorder.<ref>Gregory, R. (2006). "[http://www.psychiatrictimes.com/showArticle.jhtml?articleID=194500290 Clinical Challenges in Co-occurring Borderline Personality and Substance Use Disorders]". ''Psychiatric Times'' '''XXIII''' (13). Retrieved on [[2007-09-23]].</ref>
[[Substance abuse]] is a common problem in BPD, whether due to impulsivity or as a coping mechanism, and 50% to 70% of psychiatric inpatients with BPD have been found to meet criteria for a substance use disorder.<ref>Gregory, R. (2006). "[http://www.psychiatrictimes.com/showArticle.jhtml?articleID=194500290 Clinical Challenges in Co-occurring Borderline Personality and Substance Use Disorders]". ''Psychiatric Times'' '''XXIII''' (13). Retrieved on [[2007-09-23]].</ref>


==Etiology - causes and influences==
==Etiology - causes and influences==

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Borderline personality disorder (BPD) is defined as a mental condition characterized by emotional dysregulation, extreme "black and white" thinking, and chaotic relationships. The general profile of the disorder often includes a pervasive instability of mood, and interpersonal relationships, as well as poor self-image, and issues of identity, as well as a disturbance in the sense of self.

In extreme cases, disturbances in the sense of self can lead to periods of dissociation. [1]

Disturbances suffered by those diagnosed with Borderline personality disorder have a wide-ranging and pervasive negative impact on many facets of the person's life, including employment and relationships in work, home life, and social relationships. Co-occurence of substance abuse and mood disorders, as well as para-suicidal and suicidal behavior, is common.

Figures on the prevalence of BPD in the general population vary, ranging from approximately 1% to 2%. [2][3] The diagnosis appears to be more common in women than in men, by a ration of as much as 3:1 according to the DSM-IV-TR [4] [5]

Sufferers of BPD are also disproportionately represented in prison populations, with 23 percent of incarcerated men and 20 percent of incarcerated women are diagnosed with BPD. [6]

Origins

The term "borderline" first appeared in clinical use during the 1930s, originating with the idea posited by Otto Kernberg that some patients fell on the "borderline" between neurosis and psychosis. BPD became an official Axis II diagnosis in 1980 with the publication of the DSM-III. [2]

Category revision

Alternative suggestions for names include Emotional regulation disorder or Emotional dysregulation disorder. According to TARA, (Treatment and Research Advancement Association for Personality Disorders) this terminology has "the most likely chance of being adopted by the American Psychiatric Association."[7] Emotional regulation disorder is the term favored by Dr. Marsha Linehan, pioneer of one of the most popular types of BPD therapy. Impulse disorder and Interpersonal regulatory disorder are other valid alternatives, according to Dr. John Gunderson of McLean Hospital in the United States. Dyslimbia has been suggested by Dr. Leland Heller[8] and Mercurial disorder has been proposed by McLean Hospital's Dr. Mary Zanarini.[9]

Another term advanced (for example by psychiatrist Carolyn Quadrio) is Post Traumatic Personality Disorganisation (PTPD), reflecting the condition's status as (often) both a form of chronic Post Traumatic Stress Disorder (PTSD) and Personality Disorder and a common outcome of developmental or attachment trauma.[10]

Some who are labeled with "Borderline Personality Disorder" feel it is unhelpful and stigmatizing as well as simply inaccurate, supporting and adding to calls for a name change.[11] Criticisms have also come from a feminist perspective.[12] It has also claimed that, in some circles, "borderline" is used as a "garbage can" diagnosis for individuals who are hard to diagnose, or is interpreted as meaning "nearly psychotic" despite a lack of empirical support for this conceptualization, or is used as a generic label for difficult clients or as an excuse for therapy going badly.[13]

Diagnosis

Diagnosis is based on the self-reported experiences of the patient, as well as markers for the disorder observed by a psychiatrist, psychologist, or other qualified diagnostician through clinical assessment. This profile may be supported and/or corroborated by long term patterns of behavior as reported by family members, friends or co-workers. The list of criteria that must be met for diagnosis is outlined in the DSM-IV-TR.[1]

An initial assessment generally includes a comprehensive personal and family history, and may also include a physical examination by a physician. Although there are no physiological tests that confirm borderline personality disorder, medical tests may be employed to exclude any co-occurring medical conditions that may present with psychiatric symptoms. These include blood tests measuring TSH to exclude hypo- or hyperthyroidism, basic electrolytes and serum calcium to rule out a metabolic disturbance, full blood count including ESR to rule out a systemic infection or chronic disease, and serology to exclude syphilis or HIV infection; two commonly ordered investigations are EEG to exclude epilepsy, and a CT scan of the head to exclude brain lesions.

The World Health Organization's ICD-10 has a comparable diagnosis called Emotionally Unstable Personality Disorder - Borderline type (F60.31). This requires, in addition to the general criteria for personality disorder: disturbances in and uncertainty about self-image, aims, and internal preferences (including sexual); liability to become involved in intense and unstable relationships, often leading to emotional crisis; excessive efforts to avoid abandonment; recurrent threats or acts of self-harm; and chronic feelings of emptiness.

The Chinese Society of Psychiatry's CCMD has a comparable diagnosis of Impulsive Personality Disorder. A patient diagnosed as having IPD must display "affective outbursts" and "marked impulsive behavior", plus at least three out of eight other symptoms. The construct has been described as a hybrid of the impulsive and borderline subtypes of the ICD's Emotionally Unstable Personality Disorder, and also incorporates six of the nine DSM BPD criteria.[14]

Differential diagnosis

Borderline personality disorder often co-occurs with mood disorders. Some features of borderline personality disorder may overlap with those of mood disorders, complicating the differential diagnostic assessment.[15][16][17]

Both diagnoses involve symptoms commonly known as "mood swings". In bipolar disorder, the term refers to the cyclic episodes of elevated and depressed mood generally lasting weeks or months. In the rapid cycling variant of bipolar disorder there are more than four episodes in a year, but even then the swings are more sustained than in borderline personality disorder.

The term in borderline personality refers to the marked lability and reactivity of mood defined as emotional dysregulation. The behavior is typically in response to external psychosocial and intrapsychic stressors, and may arise and/or subside suddenly and dramatically and last for seconds, minutes, hours or days.

Bipolar depression is generally more pervasive with sleep and appetite disturbances, as well as a marked nonreactivity of mood, whereas mood with respect to borderline personality and co-occurring dysthymia remains markedly reactive and sleep disturbance not acute.[18]

The relationship between bipolar disorder and borderline personality disorder has been debated. Some hold that the latter represents a subthreshold form of affective disorder,[19][20] while others maintain the distinctness between the disorders, noting they often co-occur.[21][22]

Co-morbid diagnoses

Co-morbid (co-occurring) conditions in BPD are common. When comparing individuals diagnosed with BPD to those diagnosed with other kinds of personality disorders, the former showed a higher rate of also meeting criteria for:[23]

Substance abuse is a common problem in BPD, whether due to impulsivity or as a coping mechanism, and 50% to 70% of psychiatric inpatients with BPD have been found to meet criteria for a substance use disorder.[24]

Etiology - causes and influences

Researchers commonly believe that BPD results from a combination that can involve a traumatic childhood, a vulnerable temperament, and stressful maturational events during adolescence or adulthood.[25] Otto Kernberg formulated the theory of Borderline Personality based on a premise of failure to develop in childhood. There are, according to Kernberg, 3 developmental tasks an individual must accomplish, and, when one fails to accomplish a certain developmental task, this often corresponds with an increased risk in developing certain psychopathologies. Failing the first developmental task of psychic clarification of self and other, can result in an increased risk to develop varieties of psychosis. Not accomplishing the second task, overcoming splitting, results in an increased risk to develop a borderline personality. [26]

Childhood abuse, trauma or neglect

Numerous studies have shown a strong correlation between childhood abuse and development of BPD.[27][28][29][10] Many individuals with BPD report having had a history of abuse, neglect, or separation as young children.[30] Patients with BPD have been found to be significantly more likely to report having been verbally, emotionally, physically, and sexually abused by caretakers of either gender. They were also much more likely to report having caretakers (of both genders) deny the validity of their thoughts and feelings. They were also reported to have failed to provide needed protection, and neglected their child's physical care. Parents (of both sexes) were typically reported to have withdrawn from the child emotionally, and to have treated the child inconsistently. Additionally, women with BPD who reported a previous history of neglect by a female caretaker and abuse by a male caretaker were consequently at significantly higher risk for being sexually abused by a noncaretaker (not a parent).[31] These are also the same risk factors for reactive attachment disorder and it has been suggested that children who experience chronic early maltreatment and Reactive Attachment Disorder go on to develop a variety of personality disorders, including Borderline Personality Disorder.[32] Many of these children are violent[33] and aggressive[34] and as adults are at risk of developing a variety of psychological problems[35] such as borderline personality disorder.[32]

According to Joel Paris,[36] "Some researchers, like Judith Herman, believe that BPD is a name given to a particular manifestation of post-traumatic stress disorder (PTSD): in Trauma and Recovery, she theorizes that when PTSD takes a form that emphasizes heavily its elements of identity and relationship disturbance, it gets called BPD; when the somatic (body) elements are emphasized, it gets called hysteria, and when the dissociative/deformation of consciousness elements are the focus, it gets called DID/MPD" (dissociative identity disorder or multiple personality disorder).

Other developmental factors

Some studies suggest that BPD may not necessarily be a trauma-spectrum disorder and that it is biologically distinct from the post traumatic stress disorder that could be a precursor. The personality symptom clusters seem to be related to specific abuses, but they may be related to more persistent aspects of interpersonal and family environments in childhood.[37]

There is evidence for the central role of family in the development of BPD, including interactions that are negative and critical rather than supportive and empathic, with parental and family behaviors transacting with the child's own behaviors and emotional vulnerabilities.[38]

Some findings suggest that BPD may lie on a bipolar spectrum, with a number of points of phenomenological and biological overlap between the affective lability criterion of borderline personality disorder and the extremely rapid cycling bipolar disorders.[39][40] Some findings suggest that the DSM-IV BPD diagnosis mixes up two sets of unrelated items—an affective instability dimension related to Bipolar-II, and an impulsivity dimension not related to Bipolar-II.[41]

Genetics

An overview of the existing literature suggested that traits related to BPD are influenced by genes, and since personality is generally quite heritable then BPD should also be, but studies have had methodological problems and the links are not yet clear.[42] A major twin study found that if one identical twin met criteria for BPD, the other also met criteria in around a third (35%) of cases.[43]

Twin, sibling and other family studies indicate a partially heritable basis for impulsive aggression, but studies of serotonin-related genes to date have suggested only modest contributions to behavior.[37]

Neurological considerations

Neurotransmitters implicated in BPD include serotonin, norepinephrine and acetylcholine (related to various emotions and moods); GABA, the brain's major inhibitory neurotransmitter (which can stabilize mood change); and glutamate, an excitatory neurotransmitter.

Enhanced amygdala activation in BPD has been identified as reflecting the intense and slowly subsiding emotions commonly observed in BPD in response to even low-level stressors.Template:Fact The activation of both the amygdala and prefrontal cortical areas can reflect attempts to control intensive emotions during the recall of unresolved life events.[44] Impulsivity or aggression, as sometimes seen in BPD, has been linked to alterations in serotonin function and specific brain regions in the cingulate and the medial and orbital prefrontal cortex.[37]

References

  1. ↑ 1.0 1.1 (2004). Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR (Text Revision). Washington, DC: American Psychiatric Association. ISBN 0890420246. DSM-IV & DSM-IV-TR Borderline Personality Disorder criteria. BehaveNet.com. Retrieved on 2007-09-21.
  2. ↑ 2.0 2.1 Oldham, J. (July 2004). "Borderline Personality Disorder: An Overview" Psychiatric Times XXI (8). Retrieved on 2007-09-21.
  3. ↑ Swartz, M.; D. Blazer, L. George, et al. (1990). "Estimating the prevalence of borderline personality disorder in the community". Journal of Personality Disorders 4 (3): 257-72. Retrieved on 2007-09-23.
  4. ↑ "Diagnostic and Statistical Manual of Mental Disorders". (2000). Washington, D.C.: American Psychiatric Association 4 Text Revision.
  5. ↑ Skodol, A.E.; D.S. Bender (2003). "Why are women diagnosed borderline more than men?" Psychiatr Q 74 (4): 349-60. Retrieved on 2007-09-23.
  6. ↑ Singleton, N.; H. Meltzer, R. Gatward with The Department of Health (1998-10-13). Psychiatric morbidity among prisoners in England and Wales. London: The Stationery Office. ISBN 0116210451. Retrieved on 2007-09-21.
  7. ↑ Porr, Valerie (November 2001). How Advocacy is Bringing Borderline Personality Disorder Into the Light. tara4bpd.org Axis II. Retrieved on 2007-09-21.
  8. ↑ Heller, L. MD. "A Possible New Name For Borderline Personality Disorder". Biological Unhappiness. Retrieved on 2007-09-21.
  9. ↑ Hunter, Aina (2006-01-24). "Personality, Interrupted". The Village Voice. Retrieved on 2007-09-21.
  10. ↑ 10.0 10.1 Quadrio, C. (December 2005). "Axis One/Axis Two: A disordered borderline". Australian & New Zealand Journal of Psychiatry 39 (Suppl. 1): 141-156.
  11. ↑ Bogod, E. "Borderline Personality Disorder Label Creates Stigma". mental-health-matters.com. Retrieved on 2007-09-21.
  12. ↑ Shaw and Proctor (2005). "Women at the Margins: A Critique of the Diagnosis of Borderline Personality Disorder" (PDF). Feminism & Psychology 15: 483-90. Retrieved on 2007-09-21.
  13. ↑ Grohol, J. (June 22 2007). "Symptoms of Borderline Personality Disorder". PsychCentral.com. Retrieved on 2007-09-21.
  14. ↑ Zhong, J.; F. Leung (2007-01-05). "Should borderline personality disorder be included in the fourth edition of the Chinese classification of mental disorders?" Chin Med J (English) 120 (1): 77-82. Retrieved on 2007-09-21.
  15. ↑ Bolton, S.; J.G. Gunderson (September 1996). "Distinguishing borderline personality disorder from bipolar disorder: differential diagnosis and implications". Am J Psychiatry 153 (9): 1202-7. Retrieved on 2007-09-21.
  16. ↑ (2001). "Treatment of Patients With Borderline Personality Disorder". APA Practice Guidelines. Retrieved on 2007-09-21.
  17. ↑ "Differential Diagnosis of Borderline Personality Disorder". BPD Today. Retrieved on 2007-09-21.
  18. ↑ Goodwin, F.K.; K.R. Jamison (1990). Manic-Depressive Illness. New York: Oxford University Press, pp. 108-110. ISBN 0-19-503934-3.
  19. ↑ Akiskal, H.S.; B.I. Yerevanian, G.C. Davis, et al. (1985). "The nosologic status of borderline personality: Clinical and polysomnographic study". Am J Psychiatry (142): 192-8
  20. ↑ Gunderson, J.G.; G.R. Elliott (1985). "The interface between borderline personality disorder and affective disorder". Am J Psychiatry. (142):277-288.
  21. ↑ McGlashan, T.H. (1983). "The borderline syndrome: Is it a variant of schizophrenia or affective disorder?" Arch Gen Psychiatry. (40): 1319-23.
  22. ↑ Pope, H.G. Jr.; J.M. Jonas, J.I. Hudson, et al. (1983). "The validity of DSM-III borderline personality disorder: A phenomenologic, family history, treatment response, and long term follow up study". Arch Gen Psychiatry (40): 23-30.
  23. ↑ Zanarini, M.C.; F.R. Frankenburg, E.D. Dubo, et al. (1998). "Axis I Comorbidity of Borderline Personality Disorder". Am J Psychiatry. (155): 1733-9. Retrieved on 2007-09-23.
  24. ↑ Gregory, R. (2006). "Clinical Challenges in Co-occurring Borderline Personality and Substance Use Disorders". Psychiatric Times XXIII (13). Retrieved on 2007-09-23.
  25. ↑ Zanarini, M.C.; F.R. Frankenburg (1997). "Pathways to the development of borderline personality disorder". Journal of Personality Disorder. 11 (1): 93-104. Retrieved on 2007-09-21.
  26. ↑ Kernberg, O. (2000). Borderline Conditions and Pathological Narcissism. New York: Aronson. ISBN 0876687621.
  27. ↑ Zanarini, M.C.; J.G. Gunderson, et al. (January – February 1989). "Childhood experiences of borderline patients". Comprehensive psychiatry 30 (1): 18-25. Retrieved on 2007-09-21.
  28. ↑ Brown G.R.; B. Anderson (1991). "Psychiatric morbidity in adult inpatients with childhood histories of sexual and physical abuse". Am J Psychiatry 148 (1): 55-61. Retrieved on 2007-09-21.
  29. ↑ Herman, Judith (1997). Trauma and Recovery: The Aftermath of Violence--from Domestic Abuse to Political Terror. Basic Books. ISBN 0465087302.
  30. ↑ Zanarini M.C.; F.R. Frankenburg (1997). "Pathways to the development of borderline personality disorder". Journal of Personality Disorders 11 (1): 93-104.
  31. ↑ Zanarini, M.C.; F.R. Frankenburg (2000}. "Biparental failure in the childhood experiences of borderline patients". J Personal Disord 14 (3):264-73. Retrieved on 2007-09-21.
  32. ↑ 32.0 32.1 Dozier, M.; K. C. Stovall, et al. (1999). "Attachment and psychopathology in adulthood" in Cassidy, J.; P. Shaver (Eds.), Handbook of attachment pp. 497–519. New York: Guilford Press.
  33. ↑ Robins, L.N. (1978). "Longitudinal studies: Sturdy childhood predictors of adult antisocial behavior". Psychological Medicine (8): 611–22.
  34. ↑ Prino, C.T., & M. Peyrot (1994). "The effect of child physical abuse and neglect on aggressive withdrawn, and prosocial behavior". Child Abuse and Neglect (18): 871–84.
  35. ↑ Schreiber, R.; W. J. Lyddon (1998). "Parental bonding and current psychological functioning among childhood sexual abuse survivors". Journal of Counseling Psychology (45): 358–362.
  36. ↑ Paris, Joel MD. "Borderline Personality Disorder: What Is It, What Causes It? How Can We Treat It?" jwoodphd.com. Retrieved on 2007-09-21.
  37. ↑ 37.0 37.1 37.2 Goodman M.; A. New, L. Siever (2004). "Trauma, genes, and the neurobiology of personality disorders". Ann N Y Acad Sci (1032): 104-16. Retrieved on 2007-09-23.
  38. ↑ Fruzzetti, A.E.; C. Shenk, P.D. Hoffman (2005). "Family interaction and the development of borderline personality disorder: a transactional model". Dev Psychopathol. 17 (4): 1007-30. Retrieved on 2007-09-21.
  39. ↑ Mackinnon, D.F.; R. Pies (February 2006). "Affective instability as rapid cycling: theoretical and clinical implications for borderline personality and bipolar spectrum disorders". Bipolar Disord. 8 (1): 1-14. Retrieved on 2007-09-21.
  40. ↑ Goldberg, Ivan MD (February 2006). "MMEDLINE Citations on The Borderline-Bipolar Connection". Bipolar disord. 8 (1): 1-14. Retrieved on 2007-09-21.
  41. ↑ Benazzi, F. (January 2005). "Borderline personality-bipolar spectrum relationship". Prog Neuropsychopharmacol Biol Psychiatry 30 (1): 68-74. Retrieved on 2007-09-23.
  42. ↑ Torgersen, S. (March 2000). "Genetics of patients with borderline personality disorder". Psychiatr Clin North Am 23 (1): 1-9. Retrieved on 2007-09-23.
  43. ↑ Torgersen, S.; S. Lygren, P.A. Oien, et al. (November - December 2000). "A twin study of personality disorders". Compr Psychiatry 41 (6): 416-25. Retrieved on 2007-09-23.
  44. ↑ Beblo, T.; M. Driessen, M. Mertens, et al. (June 2006). "Functional MRI correlates of the recall of unresolved life events in borderline personality disorder". Psychol Med 36 (6): 845-56. Retrieved on 2007-09-23.

See also

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