Naranjo algorithm: Difference between revisions
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The '''Naranjo algorithm''' is a questionnaire designed by Naranjo ''et al'' for determining the likelihood of whether an ADR ([[drug toxicity|adverse drug reaction]]) is actually due to the [[medication]] rather than the result of other factors. Probability is assigned via a score termed definite, probable, possible or doubtful. | The '''Naranjo algorithm''' is a questionnaire designed by Naranjo ''et al''<ref name="pmid7249508">{{cite journal |author=Naranjo CA, Busto U, Sellers EM, ''et al'' |title=A method for estimating the probability of adverse drug reactions |journal=Clin. Pharmacol. Ther. |volume=30 |issue=2 |pages=239-45 |year=1981 |pmid=7249508 |doi=}}</ref> for determining the likelihood of whether an ADR ([[drug toxicity|adverse drug reaction]]) is actually due to the [[medication]] rather than the result of other factors. Probability is assigned via a score termed definite, probable, possible or doubtful. | ||
An alternative, simpler scale has been proposed by the [[World Health Organization]] (WHO).<ref name="pmid15148066">{{cite journal |author=Nebeker JR, Barach P, Samore MH |title=Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting |journal=Ann. Intern. Med. |volume=140 |issue=10 |pages=795–801 |year=2004 |pmid=15148066 |doi=|url=http://annals.org/cgi/content/full/140/10/795}} ([http://annals.org/cgi/content/full/140/10/795/T2 See table 2])</ref> | An alternative, simpler scale has been proposed by the [[World Health Organization]] (WHO).<ref name="pmid15148066">{{cite journal |author=Nebeker JR, Barach P, Samore MH |title=Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting |journal=Ann. Intern. Med. |volume=140 |issue=10 |pages=795–801 |year=2004 |pmid=15148066 |doi=|url=http://annals.org/cgi/content/full/140/10/795}} ([http://annals.org/cgi/content/full/140/10/795/T2 See table 2])</ref> | ||
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==References== | ==References== | ||
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==External links== | ==External links== | ||
Revision as of 08:18, 14 January 2008
The Naranjo algorithm is a questionnaire designed by Naranjo et al[1] for determining the likelihood of whether an ADR (adverse drug reaction) is actually due to the medication rather than the result of other factors. Probability is assigned via a score termed definite, probable, possible or doubtful.
An alternative, simpler scale has been proposed by the World Health Organization (WHO).[2]
Questionnaire
1. Are there previous conclusive reports on this reaction?
Yes (+1) No (0) Do not know or not done (0)
2. Did the adverse event appear after the suspected drug was given?
Yes (+2) No (-1) Do not know or not done (0)
3. Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given?
Yes (+1) No (0) Do not know or not done (0)
4. Did the adverse reaction appear when the drug was readministered?
Yes (+2) No (-1) Do not know or not done (0)
5. Are there alternative causes that could have caused the reaction?
Yes (-1) No (+2) Do not know or not done (0)
6. Did the reaction reappear when a placebo was given?
Yes (-1) No (+1) Do not know or not done (0)
7. Was the drug detected in any body fluid in toxic concentrations?
Yes (+1) No (0) Do not know or not done (0)
8. Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?
Yes (+1) No (0) Do not know or not done (0)
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
Yes (+1) No (0) Do not know or not done (0)
Scoring
- > 9 = definite ADR
- 5-8 = probable ADR
- 1-4 = possible ADR
- 0 = doubtful ADR
References
- ↑ Naranjo CA, Busto U, Sellers EM, et al (1981). "A method for estimating the probability of adverse drug reactions". Clin. Pharmacol. Ther. 30 (2): 239-45. PMID 7249508. [e]
- ↑ Nebeker JR, Barach P, Samore MH (2004). "Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting". Ann. Intern. Med. 140 (10): 795–801. PMID 15148066. [e] (See table 2)