Nelfinavir: Difference between revisions

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== External Links ==
== External Links ==
* {{DailyMed}}
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* {{MedMaster}}
* Drug Bank at http://redpoll.pharmacy.ualberta.ca/drugbank2/cgi-bin/getCard.cgi?CARD=DB00220.txt
* {{DrugBank}}

Revision as of 12:26, 5 March 2008

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Nelfinavir, a protease inhibitor.

Nelfinavir, sometimes abbreviated as NFV or NLF and sold under the brand name Viracept® is a protease inhibitor used to treat HIV/AIDS. Nelfinavir binds to and inhibits the HIV-1 viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in non-infectious, immature viral particles. Its short half-life (3.5-5 hr) and the lack of activity of it major metabolites means that nelfinavir must be taken every 4-5 hours. It most often used in combination with two or more anti-HIV drugs.

Its chemical name is (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino] -4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide, and its chemical formula is C32H45N3O4S.

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