Borna disease virus: Difference between revisions
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== Classification: == | == Classification: == | ||
== Description and significance: == | == Description and significance: == | ||
A neurotropic, noncytolytic, negative, and single-stranded enveloped RNA virus. It has a wide geographic distribution and host range,<ref name=Richt>Richt, J.A., Pfeuffer, I., Christ, M., Frese, K., Bechter, K., Herzog, S. Borna disease virus infection in animals and humans. Emerging Infectious Diseases, 3(3). 1997: 343-352.</ref> including horses, sheep, and humans. In humans, it causes a range of neurological disorders ranging from encephalitis<ref>Bode, L., Ludwig, H. Clinical similarities and close genetic relationship of human and animal Borna disease virus. Archives of Virology Supplement, 13. 1997: 167-82</ref> to manic-depressive symptoms. Some studies have demonstrated a therapeutic effect of the antiviral agent amantadine in BDV-infected, depressed patients. | A neurotropic, noncytolytic, negative, and single-stranded enveloped RNA virus. It has a wide geographic distribution and host range,<ref name=Richt>Richt, J.A., Pfeuffer, I., Christ, M., Frese, K., Bechter, K., Herzog, S. Borna disease virus infection in animals and humans. Emerging Infectious Diseases, 3(3). 1997: 343-352.</ref> including horses, sheep, and humans. In humans, it causes a range of neurological disorders ranging from encephalitis<ref>Bode, L., Ludwig, H. Clinical similarities and close genetic relationship of human and animal Borna disease virus. Archives of Virology Supplement, 13. 1997: 167-82</ref> to manic-depressive symptoms. Some studies have demonstrated a therapeutic effect of the antiviral agent amantadine in BDV-infected, depressed patients. | ||
== Natural Host: == | == Natural Host: == | ||
== When was your organism discovered? == | == When was your organism discovered? == | ||
== How and where was it isolated: == | == How and where was it isolated: == | ||
== Genome structure: == | == Genome structure: == | ||
BDV has a ca. 8.9 kb genome size of encapsulated, non-segmented, single-stranded RNA<ref name=Richt /><ref name=Torre>de la Torre, J.C. Molecular biology of Borna Disease Virus: Prototype of a new group of animal viruses. Journal of Virology, 68(12). 1994: 7669-75.</ref> with five open reading frames (ORFs).<ref>Briese, T., Schneemann, A., Lewis, A., Park, Y., Kim, H., Ludwig, H., and Lipkin, I. Genomic organization of Borna disease virus. Proceedings of the National Academy of Sciences, 91(10). 1994: 4362-66.</ref> ORFs I, II, and III correspond to 40-kDa p40, 24-kDa p24, and 14.5-kDa p14.5 BDV proteins, respectively.<ref name=Torre /> | BDV has a ca. 8.9 kb genome size of encapsulated, non-segmented, single-stranded RNA<ref name=Richt /><ref name=Torre>de la Torre, J.C. Molecular biology of Borna Disease Virus: Prototype of a new group of animal viruses. Journal of Virology, 68(12). 1994: 7669-75.</ref> with five open reading frames (ORFs).<ref>Briese, T., Schneemann, A., Lewis, A., Park, Y., Kim, H., Ludwig, H., and Lipkin, I. Genomic organization of Borna disease virus. Proceedings of the National Academy of Sciences, 91(10). 1994: 4362-66.</ref> ORFs I, II, and III correspond to 40-kDa p40, 24-kDa p24, and 14.5-kDa p14.5 BDV proteins, respectively.<ref name=Torre /> | ||
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== Interesting features: == | == Interesting features: == | ||
== How does this organism cause disease? == | == How does this organism cause disease? == | ||
== What makes it biologically interesting? == | == What makes it biologically interesting? == | ||
Its application to Biotechnology... its medical importance... major research findings made with it... what's cool about borna disease virus as an organism: | |||
== Current Research: == | == Current Research: == | ||
== References: == | == References: == | ||
Revision as of 04:41, 18 April 2009
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| Virus classification | ||||||
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Classification:
Description and significance:
A neurotropic, noncytolytic, negative, and single-stranded enveloped RNA virus. It has a wide geographic distribution and host range,[1] including horses, sheep, and humans. In humans, it causes a range of neurological disorders ranging from encephalitis[2] to manic-depressive symptoms. Some studies have demonstrated a therapeutic effect of the antiviral agent amantadine in BDV-infected, depressed patients.
Natural Host:
When was your organism discovered?
How and where was it isolated:
Genome structure:
BDV has a ca. 8.9 kb genome size of encapsulated, non-segmented, single-stranded RNA[1][3] with five open reading frames (ORFs).[4] ORFs I, II, and III correspond to 40-kDa p40, 24-kDa p24, and 14.5-kDa p14.5 BDV proteins, respectively.[3]
BDV replicates and transcribes in the nuclei of its hosts
Interesting features:
How does this organism cause disease?
What makes it biologically interesting?
Its application to Biotechnology... its medical importance... major research findings made with it... what's cool about borna disease virus as an organism:
Current Research:
References:
- ↑ 1.0 1.1 Richt, J.A., Pfeuffer, I., Christ, M., Frese, K., Bechter, K., Herzog, S. Borna disease virus infection in animals and humans. Emerging Infectious Diseases, 3(3). 1997: 343-352.
- ↑ Bode, L., Ludwig, H. Clinical similarities and close genetic relationship of human and animal Borna disease virus. Archives of Virology Supplement, 13. 1997: 167-82
- ↑ 3.0 3.1 de la Torre, J.C. Molecular biology of Borna Disease Virus: Prototype of a new group of animal viruses. Journal of Virology, 68(12). 1994: 7669-75.
- ↑ Briese, T., Schneemann, A., Lewis, A., Park, Y., Kim, H., Ludwig, H., and Lipkin, I. Genomic organization of Borna disease virus. Proceedings of the National Academy of Sciences, 91(10). 1994: 4362-66.