Evolution of appetite regulating systems

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Outline

POMC

What it is Where its found what it forms structure *diagram*

Physiology and relation to appetite regulation

Evidence for POMC related to food regulating systems Relationship between POMC and other hormones eg leptin *diagram*

Species Variation in POMC Gene

evolutionary tree diagram Chordata (vertebrates)

   ~ Agnatha – Lamprey
   ~ Gnathostomes
         ~ Chondrichthyes (cartilaginous fish)
         ~ Osteichthyes (bony fish) 
              ~ Subclass Actinopterygii (ray-finned fish;) - paddlefish
              ~ Subclass Sarcopterygii (lobe-finned fish)
                    ~ Tetrapods (mammals, birds, reptiles?)

Invertebrates

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