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'''Medical ethics''' is the study of moral values as they apply to [[medicine]].  In many cases, moral values can be in conflict, and ethical crises can result.  
'''Medical ethics''' started with [[Hippocrates]] and his oath to 'do no harm. Today the term covers a range of issues in health care and other related fields, especially the study of moral values as they apply to [[medicine]].  In many cases, moral values can be in conflict, and ethical crises can result. Medical ethics shares many principles with other areas of [[healthcare]] ethics, such as [[nursing ethics]]. A particularly controversial area of medical ethics is that of so-called reproductive ethics.


Medical ethics shares many principles with other branches of [[healthcare]] ethics, such as [[nursing ethics]].
In the 'hospital context' these include the relationship of patient and doctor, the need to obtain 'informed' consent before undertaking treatment, and related to this, the degree to which the doctor can depart from the truth when it appears in the patient's interest to do so; the allocation of healthcare resources; euthanasia and withholding of treatment (perhaps from the new born, perhaps from the very old) ; confidentiality of medical information and so on. In a research context they may include the limits of acceptability of experiments on animals - or on humans; the use of genetic information (particularly in relation to choices affecting families) ; the relationship of private profit to pubic health. The term 'bioethics' is often used interchangeably.
The idea behind medical ethics is that there is a particular kind of moral expertise that belongs not in the area of medicine but in philosophy, and hat either philosophers can be asked to express their opinions on medical matters, or medical people can be given training as philosophers. In practice, this leads to the dominance in the field of two narrow interpretations of ethics: the utilitarian calculations, epitomised by such things as the QALYs system for allocating resources (where the number of Quality Assessed Life Years for patients is counted up and compared under various treatment options, so for example a hip transplant programme may be 'better' than an expensive hear operation); and a residual notion of 'rights' in which certain treatments, (for example, being treated for a rare disease) are funded anyway, whatever the potential costs, par t of a sense of a fundamental 'right to life'. These approaches are often described as 'Kantian'.


Writers about medical ethics have suggested many methods to help resolve conflicts involving medical ethics.  Sometimes, no good solution to a dilemma in medical ethics exists, and occasionally, the values of the medical community (i.e., the hospital and its staff) conflict with the values of the individual patient, family, or larger non-medical community.
Writers about medical ethics have suggested many methods to help resolve conflicts involving medical ethics.  Sometimes, no good solution to a dilemma in medical ethics exists, and occasionally, the values of the medical community (i.e., the hospital and its staff) conflict with the values of the individual patient, family, or larger non-medical community.  
{|align="right" cellpadding="10" style="background-color:#FFFFCC; width:60%; border: 1px solid #aaa; margin:20px; font-size: 92%;"
|'''DECLARATION OF GENEVA''' (Adopted by the General Assembly of the World Medical Association, September 1948 [http://www.wma.net/e/policy/c8.htm]
 
'''At the time of being admitted as a member of the medical profession:
 
''I solemnly pledge to consecrate my life to the service of humanity;
 
''I will give to my teachers the respect and gratitude that is their due;
 
''I will practise my profession with conscience and dignity;
 
''The health of my patient will be my first consideration;
 
''I will respect the secrets that are confided in me, even after the patient has died;
 
''I will maintain by all the means in my power, the honour and the noble traditions of the medical profession;
 
''My colleagues will be my sisters and brothers;
 
''I will not permit considerations of age, disease or disability, creed, ethnic origin, gender, nationality, political affiliation, race, sexual orientation, social standing or any other factor to intervene between my duty and my patient;
 
''I will maintain the utmost respect for human life;
 
''I will not use my medical knowledge to violate human rights and civil liberties, even under threat;
 
''I make these promises solemnly, freely and upon my honour.
|}


==Values in medical ethics==
==Values in medical ethics==
Six of the values that commonly apply to medical ethics discussions are:
 
{|align="right" cellpadding="10" style="background-color:#FFFFCC; width:50%; border: 1px solid #aaa; margin:20px; font-size: 92%;"
|'''A Case Method To Assist Clinical Ethics Decision Making (Modified from '''[http://www.annals.org/cgi/content/full/128/7/576 American College of Physicians Ethics Manual])
1. Define the ethics problem as an "ought" or "should" question. (e.g." "Should we withhold a respirator for this unconscious man with AIDS, as his partner requests, or use it, as his parents request?")
 
2. List relevant facts and uncertainties. Include facts about the patient and caregivers (such as emotional state, cultural background, and legal standing). Include physiologic facts and significant medical uncertainties (such as expected outcomes with and without treatment), and the benefits and harms of treatment options.
 
3. Identify a decision maker. If the patient is competent, the decision maker is the patient. If the patient is incompetent, identify a proxy decision maker (e.g., as specified by court appointment, state law, a durable power of attorney for health care, living will, or the next of kin.)
 
4. Give understandable, relevant, desired information to the decision maker and dispel misconceptions.
 
5. Solicit values of the patient that are relevant to the question. These include the patient's values about life;  relation to community and health care institutions; goals for health care and conditions that would change goals; and preferences about health care or proxy decision makers.
 
6. Identify health professional values, including health goals (such as prolonging life and alleviating pain), values that pertain to patient–physician communication (such as truth telling and confidentiality), and some values that extend outside of the patient–physician relationship (such as promotion of public health, and respect for the law).
 
7. Propose and critique solutions, including options for treatment and alternative providers.
 
8. Identify and remove or address constraints on solutions (such as unavailability of services, laws, or legal myths).
|}
 
Six values that often apply to medical ethics discussions include:
 
 
* [[Beneficence]] - a practitioner should act in the best interest of the patient. (''Salus aegroti suprema lex''.)
* [[Beneficence]] - a practitioner should act in the best interest of the patient. (''Salus aegroti suprema lex''.)
* [[Primum non nocere|Non-maleficence]] - "first, do no harm" (''primum non nocere'').
* [[Primum non nocere|Non-maleficence]] - "first, do no harm" (''primum non nocere'').
* [[Wiktionary:autonomy|Autonomy]] - the patient has the right to refuse or choose their treatment. (''Voluntas aegroti suprema lex''.)
 
 
* [[Autonomy]] - the patient has the right to refuse or choose their treatment. (''Voluntas aegroti suprema lex''.)
 
 
* [[Justice]] - concerns the distribution of scarce health resources, and the decision of who gets what treatment.
* [[Justice]] - concerns the distribution of scarce health resources, and the decision of who gets what treatment.
* [[Dignity]] - the patient (and the person treating the patient) have the right to dignity.
* [[Dignity]] - the patient (and the person treating the patient) have the right to dignity.
* [[Truth|Truthfulness]] and [[honesty]] - the concept of [[informed consent]] has increased in importance since the historical events of the [[Nuremberg trials]] and [[Tuskegee Syphilis Study]]


These values do not give answers as to how to handle a particular situation, but they can provide a useful framework for understanding conflicts.  There are often conflicts in ethical values between the patient and family, and the medical care providers, and these can lead to ethical dilemmas. Conflicts can also arise between health care providers, or among family members. For example, the principles of ''autonomy'' and ''beneficence'' clash when patients refuse life-saving [[blood transfusion]], and ''truth-telling'' was not strongly emphasized before the HIV era.
 
* [[Truth|Truthfulness]] and [[honesty]]
 
 
 
These values do not give answers as to how to handle a particular situation, but they can provide a useful framework for understanding conflicts.  There are often conflicts in ethical values between the patient and family, and the medical care providers, and these can lead to ethical dilemmas. Conflicts can also arise between health care providers, or among family members. For example, the principles of ''autonomy'' and ''beneficence'' clash when patients refuse life-saving [[blood transfusion]], and ''truth-telling'' was not strongly emphasized before the HIV era.


In the United Kingdom, the [[General Medical Council]] provides guidance in the form of its  '[http://www.gmc-uk.org/guidance/good_medical_practice/index.asp Good Medical Practice]' statement.
In the United Kingdom, the [[General Medical Council]] provides guidance in the form of its  '[http://www.gmc-uk.org/guidance/good_medical_practice/index.asp Good Medical Practice]' statement.
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==Informed consent==
==Informed consent==
{{main|Informed consent}}
{{main|Informed consent}}
'''Informed Consent''' in ethics usually refers to the idea that someone who is not adequately informed about the full implications of a decision about his or her treatment is at risk of mistakenly making a choice not reflective of his or her ethical values.  It does not specifically mean the ''process'' of obtaining consent, nor the legal requirements for [[decision-making capacity]]. Patients can choose to make their own medical decisions, or can delegate this authority to someone else. Sometimes, the patient may be incapacitated, in which case U.S. State law designates a process for obtaining informed consent. In some American States, family members have differing levels of precedence over one another in making medical decisions for the patient, while other States recognize all family members equally in making medical decisions.
'''Informed Consent''' usually refers to the idea that someone who is not adequately informed about the full implications of a decision about his or her treatment is at risk of mistakenly making a choice not reflective of his or her ethical values.  It does not specifically mean the ''process'' of obtaining consent, nor the legal requirements for [[decision-making capacity]]. Patients can choose to make their own medical decisions, or can delegate this authority to someone else. Sometimes, the patient may be incapacitated, in which case U.S. State law designates a process for obtaining informed consent. In some American States, family members have differing levels of precedence over one another in making medical decisions for the patient, while other States recognize all family members equally in making medical decisions.


The value of informed consent is closely related to the values of ''autonomy'' and ''truth telling''.  American culture places a high value on these principles, finding justification in the U.S. Constitution and Declaration of Independence.
The value of informed consent is closely related to the values of ''autonomy'' and ''truth telling''.  American culture places a high value on these principles, finding justification in the U.S. Constitution and Declaration of Independence. The concept of [[informed consent]] has increased in importance since the [[Nuremberg trials]] and the [[Tuskegee Syphilis Study]]


==Confidentiality==
==Confidentiality==
{{main|Confidentiality}}
{{main|Confidentiality}}
'''Confidentiality''' is commonly applied to conversations between doctors and patients.  This concept is commonly known as patient-physician privilege. Legal protections prevent physicians from revealing their discussions with patients, even under oath in court. Confidentiality is mandated in [[America]] by [[HIPAA]] laws, specifically the Privacy Rule. Confidentiality is challenged in cases such as the diagnosis of a sexually transmitted disease in a patient who refuses to reveal the diagnosis to a spouse, or in the termination of a pregnancy in an underage patient, without the knowledge of the patient's parents. Many states in the U.S. have laws governing parental notification in underage abortion[http://www.ncsl.org/programs/health/adolabor.htm]
<blockquote>''"Confidentiality is a fundamental tenet of medical care. It is a matter of respecting the privacy of patients, encouraging them to seek medical care and discuss their problems candidly, and preventing discrimination on the basis of their medical conditions."'' [http://www.annals.org/cgi/content/full/128/7/576 American College of Physicians, Ethics Manual, Fourth Edition]</blockquote>
 
<blockquote>
''"A physician shall respect the rights of patients, colleagues, and other health professionals, and shall safeguard patient confidences and privacy within the constraints of the law."'' [http://www.ama-assn.org/ama/pub/category/2512.html AMA Principles of Medical Ethics]
</blockquote>
 
'''Confidentiality''' applies especially to conversations between doctors and patients, and is commonly known as "patient-physician privilege". Legal protections prevent physicians from revealing their discussions with patients, even under oath in court. Confidentiality is mandated in the USA by [[HIPAA]] laws, specifically the Privacy Rule. Confidentiality is challenged in cases such as the diagnosis of a sexually transmitted disease in a patient who refuses to reveal the diagnosis to a spouse, or in the termination of a pregnancy in an underage patient, without the knowledge of the patient's parents. Many States in the USA have laws governing parental notification in underage abortion[http://www.ncsl.org/programs/health/adolabor.htm]


==Beneficence==
==Beneficence==
The principle of ''beneficence'' expresses the duty of health care providers to be of a benefit to the patient, as well as to take active steps to prevent and to remove harm from the patient.
===Bedside rationing===
Bedside rationing is defined as when the following conditions exist regarding the physician's actions:<ref name="pmid8992926">{{cite journal |author=Ubel PA, Goold S |title=Recognizing bedside rationing: clear cases and tough calls |journal=Ann. Intern. Med. |volume=126 |issue=1 |pages=74–80 |year=1997 |month=January |pmid=8992926 |doi= |url=http://www.annals.org/cgi/pmidlookup?view=long&pmid=8992926 |issn=}}</ref>
# "withhold, withdraw, or fail to recommend a service that, in the physician's best clinical judgment, is in the patient's best medical interests"
# "act primarily to promote the financial interests of someone other than the patient (including an organization, society at large, and the physician himself or herself)"
# "have control over the use of the beneficial service"
The physician's role in rationing is debated; however, even among proponents of the physician's role there is an emphasis that the physician should not make a rationing decision in isoloation.<ref name="pmid10896641">{{cite journal |author=Pearson SD |title=Caring and cost: the challenge for physician advocacy |journal=Ann. Intern. Med. |volume=133 |issue=2 |pages=148–53 |year=2000 |month=July |pmid=10896641 |doi= |url=http://www.annals.org/cgi/pmidlookup?view=long&pmid=10896641 |issn=}}</ref><ref name="pmid18420552">{{cite journal |author=Strech D, Synofzik M, Marckmann G |title=How physicians allocate scarce resources at the bedside: a systematic review of qualitative studies |journal=J Med Philos |volume=33 |issue=1 |pages=80–99 |year=2008 |month=February |pmid=18420552 |doi=10.1093/jmp/jhm007 |url=http://jmp.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=18420552 |issn=}}</ref>


==Autonomy==
==Autonomy==
==Justice==
Justice in health care is usually defined as a form of fairness,and in medicine it means that when access to health care is limited, then some fair way of allocating those scarce resources must be found.
It is generally accepted that persons who are equals should qualify for equal treatment; for example, Medicare is available to all persons over the age of 65 years. This category of persons is equal with respect to their age, but says nothing about need or other factors about the persons in this category. One of the most controversial issues in modern health care is "who has the right to health care?"  Most generally, as a society, do we want to provide some minimum level of health care for all citizens, regardless of ability to pay? More particularly, if scarce resources mean that only some people can be treated, how should they be chosen?


==Non-maleficence==
==Non-maleficence==


The concept of ''non-maleficence'' is embodied by the phrase, "first, do no harm," (in Latin, ''[[primum non nocere]]'').  Physicians are obliged, under medical ethics, to not prescribe medications they know to be harmful.  American physicians interpret this value to exclude the practice of [[euthanasia]], though not all concur. Probably the most extreme example in recent history of the violation of the non-maleficence dictum was Dr [[Jack Kevorkian]], who was convicted of second-degree homicide in Michigan in 1998 after demonstrating active euthanasia on the TV news show ''60 Minutes''.
The concept of ''non-maleficence'' is embodied by the phrase, "first, do no harm," (in Latin, ''primum non nocere'').  Physicians must not prescribe medications they know to be harmful.  American physicians interpret this to exclude the practice of [[euthanasia]], but not all concur. For example, Dr Jack Kevorkian was convicted of second-degree homicide in Michigan in 1998 after demonstrating active euthanasia on the TV news show ''60 Minutes''.[http://news.bbc.co.uk/1/hi/health/background_briefings/euthanasia/331269.stm] Dr Kekorvian, who claims that he participated in at least 130 assisted suicides, was released in January 2007 after eight years in prison.


Non-maleficence is a legally definable concept.  Violation of non-maleficence is the subject of [[medical malpractice]] litigation.
Non-maleficence is a legally definable concept.  Violation of non-maleficence is the subject of [[medical malpractice]] litigation.
===Double effect===
===Double effect===
Some interventions undertaken by physicians can create a positive outcome while also potentially doing harm, a combination known as the "double effect."  One example of this is the use of morphine in the dying patient.  Morphine can ease the pain and suffering of the patient, while simultaneously hastening the patient's demise by suppressing the respiratory drive.
Some interventions undertaken by physicians can have a beneficial outcome while also potentially doing harm, a combination known as the "double effect."  One example is the use of morphine in the dying patient: morphine can ease the pain and suffering of the patient, while simultaneously hastening the patient's demise by suppressing the respiratory drive.
 
The concept was first formulated, in a more general ethical context, by [[Thomas Aquinas]].


==Importance of communication==
==Importance of communication==
Many so-called "ethical conflicts" in medical ethics can be traced back to a lack of communication. Communication breakdowns between patients and their healthcare team, between family members, or between members of the medical community, can all lead to disagreements and strong feelings.  These breakdowns should be remedied, and many apparently insurmountable "ethics" problems can be solved with open communication.
Many "ethical conflicts" can be traced back to a lack of communication. Communication breakdowns between patients and their healthcare team, between family members, or between members of the medical community, can all lead to disagreements and strong feelings.  These breakdowns should be remedied, and many apparently insurmountable "ethical" problems can be solved with open communication.


==Ethics committees==
==Ethics committees==
Many times, simple communication is not enough to resolve a conflict, and a hospital ethics committee, comprised of heath care professionals, clergy, and lay people, must convene to decide a complex matter.
Often, simple communication is not enough to resolve a conflict, and a hospital ethics committee, comprised of heath care professionals, clergy, and lay people, must convene to decide a complex matter.


==Cultural concerns==
==Cultural concerns==
Cultural differences can create difficult medical ethics problems.  Some cultures have spiritual or magical theories about the origins of disease, for example, and reconciling these beliefs with the tenets of Western medicine can be difficult.   
Cultural differences can create difficult medical ethics problems.  Some cultures have spiritual or magical theories about the origins of disease, for example, and reconciling these beliefs with the tenets of Western medicine can be difficult.   
===Truth-telling===
===Truth-telling===
Some cultures do not place a great emphasis on informing the patient of the diagnosis, especially when cancer is the diagnosis.  Even American culture did not emphasize truth-telling in a cancer case until the 1970's.  In American medicine, the principle of [[informed consent]] takes precedence over other ethical values, and patients are usually at least asked whether they want to know the diagnosis.
Some cultures do not place a great emphasis on informing the patient of the diagnosis, especially when cancer is the diagnosis.  Even American culture did not emphasize truth-telling in a cancer case until the 1970's.  In American medicine, the principle of [[informed consent]] takes precedence over other ethical values, and patients are usually at least asked whether they want to know the diagnosis.


==Conflicts of interest==
==Conflicts of interest==
{{main|Conflict of interest}}
<blockquote>''"A physician shall, while caring for a patient, regard responsibility to the patient as paramount."'' Article VIII of the AMA [http://www.ama-assn.org/ama/pub/category/2512.html Principles of medical ethics]</blockquote>
Physicians should not allow a conflict of interest to influence medical judgment.  In some cases, conflicts are hard to avoid, and doctors have a responsibility to avoid entering such situations.
Physicians should not allow a conflict of interest to influence medical judgment.  In some cases, conflicts are hard to avoid, and doctors have a responsibility to avoid entering such situations.
===Self-referral===
For example, doctors who receive income from referring patients for medical tests have been shown to refer more patients for medical tests <ref name="pmid1406882">{{cite journal |author=Swedlow A, Johnson G, Smithline N, Milstein A |title=Increased costs and rates of use in the California workers' compensation system as a result of self-referral by physicians |journal=N Engl J Med |volume=327 |issue=21 |pages=1502-6 |year=1992 |pmid=1406882}}</ref>. This practice is proscribed by the American College of Physicians Ethics Manual <ref name="pmid9518406 | ">{{cite journal |author= |title=Ethics manual. Fourth edition. American College of Physicians |journal=Ann Intern Med |volume=128 |issue=7 |pages=576-94 |year=1998 |pmid=9518406 | url=http://www.annals.org/cgi/content/full/128/7/576}}</ref>.
===Vendor relationships===
====Effect on the conduct of patient care====
In the USA, a survey reported that 28% of practicing physicians reported receiving money from industry for consulting, giving lectures, or enrolling patients in trials <ref name="pmid17460228">{{cite journal |author=Campbell EG ''et al.'' |title=A national survey of physician-industry relationships |journal=N Engl J Med |volume=356 |pages=1742–50 |year=2007 |pmid=17460228 |doi=10.1056/NEJMsa064508}}</ref> with amounts arranging from  $100-$20,000.<ref name="pmid17374816">{{cite journal |author=Ross JS ''et al.'' |title=Pharmaceutical company payments to physicians: early experiences with disclosure laws in Vermont and Minnesota |journal=JAMA |volume=297  |pages=1216–23 |year=2007 |pmid=17374816 |doi=10.1001/jama.297.11.1216 |issn=}}</ref> Studies show that doctors can be influenced by drug company inducements, including gifts and food.<ref>{{cite journal |author=Güldal D, Semin S |title=The influences of drug companies' advertising programs on physicians |journal=Int J Health Serv |volume=30 |pages=585-95 |year=2000 |pmid=11109183}}</ref>
Industry-sponsored Continuing Medical Education (CME) programs influence prescribing patterns.
<ref>{{cite journal |author=Wazana A |title=Physicians and the pharmaceutical industry: is a gift ever just a gift? |journal=JAMA |volume=283 |pages=373-80 |year=2000 |pmid=10647801}}</ref>
Many patients surveyed in one study agreed that physician gifts from drug companies influence prescribing practices.
<ref>{{cite journal |author=Blake R, Early E |title=Patients' attitudes about gifts to physicians from pharmaceutical companies |journal=J Am Board Fam Pract |volume=8 |pages=457-64 |year= |pmid=8585404}}</ref>
A growing movement among physicians is attempting to diminish the influence of pharmaceutical industry marketing upon medical practice, as evidenced by Stanford University's ban on drug company-sponsored lunches and gifts.  Other academic institutions that have banned pharmaceutical industry-sponsored gifts and food include the University of Pennsylvania, and Yale University.
<ref>[http://www.montereyherald.com/mld/montereyherald/living/health/16680875.htm]  LA Times, "Drug money withdrawals:
Medical schools review rules on pharmaceutical freebies," posted 2/12/07, accessed 3/6/07]</ref>
====Effect on the conduct of research and publishing====
Financial relationships with pharmaceutical manufacturers are associated with authors' published positions.<ref name="pmid9420342">{{cite journal |author=Stelfox HT, Chua G, O'Rourke K, Detsky AS |title=Conflict of interest in the debate over calcium-channel antagonists |journal=N. Engl. J. Med. |volume=338 |issue=2 |pages=101–6 |year=1998 |pmid=9420342 |doi=}}</ref> Faculty members<ref name="pmid9103347">{{cite journal |author=Blumenthal D, Campbell EG, Anderson MS, Causino N, Louis KS |title=Withholding research results in academic life science. Evidence from a national survey of faculty |journal=JAMA |volume=277 |issue=15 |pages=1224–8 |year=1997 |pmid=9103347 |doi=}}</ref><ref name="pmid8929266">{{cite journal |author=Blumenthal D, Campbell EG, Causino N, Louis KS |title=Participation of life-science faculty in research relationships with industry |journal=N. Engl. J. Med. |volume=335 |issue=23 |pages=1734–9 |year=1996 |pmid=8929266 |doi=}}</ref> and institutions<ref name="pmid8538709">{{cite journal |author=Blumenthal D, Causino N, Campbell E, Louis KS |title=Relationships between academic institutions and industry in the life sciences--an industry survey |journal=N. Engl. J. Med. |volume=334 |issue=6 |pages=368–73 |year=1996 |pmid=8538709 |doi=}}</ref> with entrepreneurial relationships are associated with data withholding from colleagues or publication.
====Conflict of interest in research====
In any publication, there is always some issue with regard to conflict of interest. All the work by scientists is funded by groups such as charities, public bodies or private industry. Accordingly there could be pressure to overstate any outcomes or bias a trial to favor a particular outcome. Unfortunately, the presence of authors with a conflict of interest is not reliably indicated in journal articles.<ref name="pmid11405896">{{cite journal |author=Papanikolaou GN ''et al.''|title=Reporting of conflicts of interest in guidelines of preventive and therapeutic interventions |journal=BMC medical research methodology |volume=1  |pages=3 |year=2001 |pmid=11405896 |doi=}}</ref> Worse it has been reported that some published articles use 'ghost writers'.<ref name="pmid16230729">{{cite journal |author=Laine C, Mulrow CD |title=Exorcising ghosts and unwelcome guests |journal=Ann Intern. Med |volume=143  |pages=611–2 |year=2005 |pmid=16230729 |doi=|url=http://www.annals.org/cgi/content/full/143/8/611}}</ref> Ghost writers may have a conflict of interest but this is not apparent since they are not credited as an author in the byline. Finally, academic scientists gain their professional reputations by publishing in quality journals and purely factual summaries do not necessarily impress journal editors any more than they inspire casual readers.
In the design of [[randomized controlled trial]]s, industry-sponsored studies may be more likely to select an inappropriate comparator group that would favor finding benefit in the experimental group. This may manifest itself by comparing the effectiveness of a new drug with the effectiveness of an established older treatment rather than choosing a competitors current treatment for comparison.<ref name="pmid12775614">{{cite journal |author=Lexchin J ''et al.'' |title=Pharmaceutical industry sponsorship and research outcome and quality: systematic review |journal=BMJ |volume=326 |pages=1167–70 |year=2003 |pmid=12775614 |doi=10.1136/bmj.326.7400.1167}}</ref> When reporting data from randomized controlled trials, industry-sponsored studies may be more likely to omit [[intention-to-treat]] analyses.<ref name="pmid12775615">{{cite journal |author=Melander H ''et al.'' |title=Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications |journal=BMJ |volume=326 |pages=1171–3 |year=2003 |pmid=12775615 |doi=10.1136/bmj.326.7400.1171}}</ref> Regarding the conclusions reached in randomized controlled trials,  industry sponsored studies may be more likely to conclude that drugs are safe, even when they have increased adverse effects.<ref name="pmid17954797">{{cite journal |author=Nieto A ''et al.'' |title=Adverse effects of inhaled corticosteroids in funded and nonfunded studies |journal=Arch Intern Med |volume=167 |pages=2047–53 |year=2007 |pmid=17954797 |doi=10.1001/archinte.167.19.2047}}</ref> Alternatively, the usefulness of drugs may be overstated, although, this is contentious since one study did not find evidence of overstatement.<ref name="pmid10535436">{{cite journal |author=Friedberg M ''et al.'' |title=Evaluation of conflict of interest in economic analyses of new drugs used in oncology |journal=JAMA |volume=282 |pages=1453–7 |year=1999 |pmid=10535436 |doi=}}</ref> in contrast, a later study found that industry sponsored studies are more likely to recommend the experimental drug as treatment of choice even after adjusting for the treatment effect.<ref name="pmid12928469">{{cite journal |author=Als-Nielsen B ''et al.''|title=Association of funding and conclusions in randomized drug trials: a reflection of treatment effect or adverse events? |journal=JAMA |volume=290 |pages=921–8 |year=2003 |pmid=12928469 |doi=10.1001/jama.290.7.921}}</ref>
Obviously a pharmaceutical company wants to report that its drug is better than a competitor's drug, or better than no treatment, however, due to the threat of litigation, it is not in their interests to suppress or minimise evidence of harm. For the scientists who are conducting the trials, however, the perspective might be different: if it becomes clear that a drug is useless or harmful, then the company will cease to work on the drug and a scientists livelyhood could be threatened. Consequently, the responsibility for the integrity of the design and analysis of studies lies squarely with the authors. If the scientists involved in any trial are lacking in competence or integrity, then this will prejudice the value of a trial both for the public and indeed for their industrial sponsors.
===Treatment of family members===
Many doctors treat their family members.  Doctors who do so must be vigilant not to create conflicts of interest or treat inappropriately.<ref name="pmid1922224">{{cite journal |author=La Puma J, Stocking C, La Voie D, Darling C |title=When physicians treat members of their own families. Practices in a community hospital |journal=N Engl J Med |volume=325 |issue=18 |pages=1290-4 |year=1991 |pmid=1922224}}</ref><ref name="pmid1545466">{{cite journal |author=La Puma J, Priest E |title=Is there a doctor in the house? An analysis of the practice of physicians' treating their own families |journal=JAMA |volume=267 |issue=13 |pages=1810-2 |year=1992 |pmid=1545466}}</ref>.
===Sexual relationships===
Sexual relationships between doctors and patients can create ethical conflicts, since sexual consent may conflict with the fiduciary responsibility of the physician. Doctors who enter into sexual relationships with patients face the threats of deregistration and prosecution. It is estimated that between 2% and 9% of doctors have violated this rule based on a study in the early 1990s <ref name="pmid1441462">{{cite journal |author=Gartrell N, Milliken N, Goodson W, Thiemann S, Lo B |title=Physician-patient sexual contact. Prevalence and problems |journal=West J Med |volume=157 |issue=2 |pages=139-43 |year=1992 |pmid=1441462}}</ref>.


==Futility==
==Futility==
Advanced directives include living wills and durable powers of attorney for healthcare. (''See also [[Do Not Resuscitate]] and [[cardiopulmonary resuscitation]]'')  In many cases, the "expressed wishes" of the patient are documented in these directives, and this provides a framework to guide family members and health care professionals in decisionmaking when the patient is incapacitated.  Undocumented expressed wishes can also help guide decisionmaking, in the absence of advanced directives.  "Substituted judgement" is the concept that a family member can give consent for treatment if the patient is unable (or unwilling) to give consent himself.  The key question for the decisionmaking surrogate is not, "What would you like to do," but instead, "What do you think the patient would want in this situation."
''Advanced directives'' include living wills and durable powers of attorney for healthcare.   Often, these directives document the "expressed wishes" of the patient, and this provides a framework to guide family members and health care professionals in decisionmaking when the patient is incapacitated.  Undocumented expressed wishes can also help guide decisionmaking, in the absence of advanced directives.  "Substituted judgement" is the concept that a family member can give consent for treatment if the patient is unable (or unwilling) to give consent himself.  The key question for the decisionmaking surrogate is not, "What would you like to do," but "What do you think the patient would want in this situation."
Courts have supported family's arbitrary definitions of futility to include simple biological survival, as in the [[Baby K]] case. A more in-depth discussion of futility is available at [[medical futility]].
Courts in the USA have supported family's arbitrary definitions of futility to include simple biological survival, as in the case of "Baby K". <ref>Baby K, who was born on October 13 1992, was diagnosed prenatally as being anencephalic (with minimal development of brain tissue). This condition is untreatable, and infants usually survive only a few weeks. Despite medical advice, the mother carried Baby K to term. At her mother's insistence, Baby K was intubated and placed on mechanical ventilation. In conjunction with an ethics committee, the physicians recommended a ''do not resuscitate'' order, but her mother rejected the recommendation, and the infant eventually was weaned off of the ventilator. In the following months, Baby K was readmitted several times for respiratory distress and apnea. At 6 months of age, a tracheostomy was performed, and the hospital then filed a motion in federal court for appointment of a guardian and a declaration that the hospital could provide only palliative care. The appointed guardian agreed that aggressive treatment should be stopped, but the district court ruled that the hospital was legally obliged to provide ventilator treatment to Baby K. On February 10, 1994, the Appeals court ruled that the hospital was not authorized to decline to provide stabilizing treatment, which it considered ethically inappropriate, to this anencephalic infant or to any patient presenting with an emergency condition. Baby K spent many months in intensive care, and died of cardiac arrest in April 1995.[http://www.medscape.com/viewarticle/464018_4]</ref>


* [[Baby Doe Law]] Establishes state protection for a disabled child's right to life, ensuring that this right is protected even over the wishes of parents or guardians in cases where they want to withhold treatment.
* [[Baby Doe Law]] Establishes state protection for a disabled child's right to life, ensuring that this right is protected even over the wishes of parents or guardians in cases where they want to withhold treatment.
'''A Case Method To Assist Clinical Ethics Decision Making'''
1. Define the ethics problem as an "ought" or "should" question. (e.g." "Should we withhold a respirator for this unconscious adult man with AIDS, as his partner requests, or use it, as his parents request?")
2. List significant facts and uncertainties that are relevant to the question. Include facts about the patient and caregivers (such as emotional state, ethnic and cultural background,  and legal standing). Include physiologic facts, significant medical uncertainties (such as prognosis and outcomes with and without treatment), and the benefits and harms of the treatment options.
3. Identify a decision maker. If the patient is competent, the decision maker is the patient. If the patient is incompetent or lacks decision-making capacity, identify a proxy decision maker as specified by court appointment, state law, a durable power of attorney for health care, living will, or the persons who are best situated by virtue of their intimate, loving familiarity with the patient.
4. Give understandable, relevant, desired information to the decision maker and dispel myths and misconceptions.
5. Solicit values of the patient that are relevant to the question. These include the patient's values about life; place in the life cycle; relation to community, health care, and health care institutions; goals for health care and conditions that would change goals; and specific preferences about health care or proxy decision makers that are relevant to this situation.
6. Identify health professional values, including health-promoting goals (such as prolonging life and alleviating pain), values that pertain to patient–physician communication (such as truth telling and confidentiality), and some values that extend outside of the patient–physician relationship (such as promotion of public health, and respect for the law).
7. Propose and critique solutions, including options for treatment and alternative providers.
8. Identify and remove or address constraints on solutions (such as unavailability of services, laws, or legal myths).
==See also==
*[[Euthanasia]]
*[[Hastings Center]]
*[[Hippocratic Oath]]
*[[Medical Law International]]
*[[World Medical Association]]
===Reproductive medicine===
*Accessibility of [[abortion]]
*[[Bioethics of neonatal circumcision]]
*[[Cloning]]
*[[Eugenics]]
*[[genetics|Genetic]] manipulation
===Medical research===
*[[Animal_testing|Animal research]]
*[[CIOMS Guidelines]]
* [http://www.nihtraining.com/ohsrsite/guidelines/45cfr46.html Common rule]s. Adopted by 17 United States departments and agencies (1991).
*[[Nuremberg Code]]
*[[Declaration of Geneva]]
*[[Declaration of Helsinki]]
*[[Declaration of Tokyo]]
*[[Good clinical practice]]
*[[Health Insurance Portability and Accountability Act]]
*[[US Patients' Bill of Rights|Patients' Bill of Rights]]
*[[Universal Declaration of Human Rights]]
*[[Institutional Review Board]]
===Famous cases in medical ethics===
Many famous cases in medical ethics illustrate and helped define important issues.
*[[Willowbrook State School|Willowbrook Study]]
*[[Tuskegee Syphilis Study]]
*[[Terry Schiavo]]
*[[Jack Kervorkian]]
*[[Nancy Cruzan]]
*[[Karen Ann Quinlan]]
*[[Baby K]]
*[[HeLa]]
===Distribution and utilization of research and care===
*Accessibility of [[health care]]
*Basis of priority for [[organ transplant]]ation
*Institutionalization of care access through [[Health maintenance organization|HMOs]] and medical [[insurance]] companies


==References==
==References==
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==External links==
==External links==
* [http://jme.bmjjournals.com/ BMJJournals.com] - An international peer review journal for health professionals and researchers in medical ethics
# Lois Snyder for the American College of Physicians Ethics, Professionalism, and Human Rights Committee. (2011) [http://www.annals.org/content/156/1_Part_2/73.full American College of Physicians Ethics Manual: Sixth Edition][[Category:Suggestion Bot Tag]]
* [http://www.publicationethics.org.uk/guidelines Committee on Publication Ethics] COPE is a forum for editors of peer-reviewed journals in biomedical sciences to discuss issues related to the integrity of the scientific record. Cope publishes guidelines on good practice for editors, and reports on breaches of ethics.

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Medical ethics started with Hippocrates and his oath to 'do no harm. Today the term covers a range of issues in health care and other related fields, especially the study of moral values as they apply to medicine. In many cases, moral values can be in conflict, and ethical crises can result. Medical ethics shares many principles with other areas of healthcare ethics, such as nursing ethics. A particularly controversial area of medical ethics is that of so-called reproductive ethics.

In the 'hospital context' these include the relationship of patient and doctor, the need to obtain 'informed' consent before undertaking treatment, and related to this, the degree to which the doctor can depart from the truth when it appears in the patient's interest to do so; the allocation of healthcare resources; euthanasia and withholding of treatment (perhaps from the new born, perhaps from the very old) ; confidentiality of medical information and so on. In a research context they may include the limits of acceptability of experiments on animals - or on humans; the use of genetic information (particularly in relation to choices affecting families) ; the relationship of private profit to pubic health. The term 'bioethics' is often used interchangeably.

The idea behind medical ethics is that there is a particular kind of moral expertise that belongs not in the area of medicine but in philosophy, and hat either philosophers can be asked to express their opinions on medical matters, or medical people can be given training as philosophers. In practice, this leads to the dominance in the field of two narrow interpretations of ethics: the utilitarian calculations, epitomised by such things as the QALYs system for allocating resources (where the number of Quality Assessed Life Years for patients is counted up and compared under various treatment options, so for example a hip transplant programme may be 'better' than an expensive hear operation); and a residual notion of 'rights' in which certain treatments, (for example, being treated for a rare disease) are funded anyway, whatever the potential costs, par t of a sense of a fundamental 'right to life'. These approaches are often described as 'Kantian'.

Writers about medical ethics have suggested many methods to help resolve conflicts involving medical ethics. Sometimes, no good solution to a dilemma in medical ethics exists, and occasionally, the values of the medical community (i.e., the hospital and its staff) conflict with the values of the individual patient, family, or larger non-medical community.

DECLARATION OF GENEVA (Adopted by the General Assembly of the World Medical Association, September 1948 [2]

At the time of being admitted as a member of the medical profession:

I solemnly pledge to consecrate my life to the service of humanity;

I will give to my teachers the respect and gratitude that is their due;

I will practise my profession with conscience and dignity;

The health of my patient will be my first consideration;

I will respect the secrets that are confided in me, even after the patient has died;

I will maintain by all the means in my power, the honour and the noble traditions of the medical profession;

My colleagues will be my sisters and brothers;

I will not permit considerations of age, disease or disability, creed, ethnic origin, gender, nationality, political affiliation, race, sexual orientation, social standing or any other factor to intervene between my duty and my patient;

I will maintain the utmost respect for human life;

I will not use my medical knowledge to violate human rights and civil liberties, even under threat;

I make these promises solemnly, freely and upon my honour.

Values in medical ethics

A Case Method To Assist Clinical Ethics Decision Making (Modified from American College of Physicians Ethics Manual)

1. Define the ethics problem as an "ought" or "should" question. (e.g." "Should we withhold a respirator for this unconscious man with AIDS, as his partner requests, or use it, as his parents request?")

2. List relevant facts and uncertainties. Include facts about the patient and caregivers (such as emotional state, cultural background, and legal standing). Include physiologic facts and significant medical uncertainties (such as expected outcomes with and without treatment), and the benefits and harms of treatment options.

3. Identify a decision maker. If the patient is competent, the decision maker is the patient. If the patient is incompetent, identify a proxy decision maker (e.g., as specified by court appointment, state law, a durable power of attorney for health care, living will, or the next of kin.)

4. Give understandable, relevant, desired information to the decision maker and dispel misconceptions.

5. Solicit values of the patient that are relevant to the question. These include the patient's values about life; relation to community and health care institutions; goals for health care and conditions that would change goals; and preferences about health care or proxy decision makers.

6. Identify health professional values, including health goals (such as prolonging life and alleviating pain), values that pertain to patient–physician communication (such as truth telling and confidentiality), and some values that extend outside of the patient–physician relationship (such as promotion of public health, and respect for the law).

7. Propose and critique solutions, including options for treatment and alternative providers.

8. Identify and remove or address constraints on solutions (such as unavailability of services, laws, or legal myths).

Six values that often apply to medical ethics discussions include:


  • Beneficence - a practitioner should act in the best interest of the patient. (Salus aegroti suprema lex.)



  • Autonomy - the patient has the right to refuse or choose their treatment. (Voluntas aegroti suprema lex.)


  • Justice - concerns the distribution of scarce health resources, and the decision of who gets what treatment.


  • Dignity - the patient (and the person treating the patient) have the right to dignity.



These values do not give answers as to how to handle a particular situation, but they can provide a useful framework for understanding conflicts. There are often conflicts in ethical values between the patient and family, and the medical care providers, and these can lead to ethical dilemmas. Conflicts can also arise between health care providers, or among family members. For example, the principles of autonomy and beneficence clash when patients refuse life-saving blood transfusion, and truth-telling was not strongly emphasized before the HIV era.

In the United Kingdom, the General Medical Council provides guidance in the form of its 'Good Medical Practice' statement.

Informed consent

For more information, see: Informed consent.

Informed Consent usually refers to the idea that someone who is not adequately informed about the full implications of a decision about his or her treatment is at risk of mistakenly making a choice not reflective of his or her ethical values. It does not specifically mean the process of obtaining consent, nor the legal requirements for decision-making capacity. Patients can choose to make their own medical decisions, or can delegate this authority to someone else. Sometimes, the patient may be incapacitated, in which case U.S. State law designates a process for obtaining informed consent. In some American States, family members have differing levels of precedence over one another in making medical decisions for the patient, while other States recognize all family members equally in making medical decisions.

The value of informed consent is closely related to the values of autonomy and truth telling. American culture places a high value on these principles, finding justification in the U.S. Constitution and Declaration of Independence. The concept of informed consent has increased in importance since the Nuremberg trials and the Tuskegee Syphilis Study

Confidentiality

For more information, see: Confidentiality.

"Confidentiality is a fundamental tenet of medical care. It is a matter of respecting the privacy of patients, encouraging them to seek medical care and discuss their problems candidly, and preventing discrimination on the basis of their medical conditions." American College of Physicians, Ethics Manual, Fourth Edition

"A physician shall respect the rights of patients, colleagues, and other health professionals, and shall safeguard patient confidences and privacy within the constraints of the law." AMA Principles of Medical Ethics

Confidentiality applies especially to conversations between doctors and patients, and is commonly known as "patient-physician privilege". Legal protections prevent physicians from revealing their discussions with patients, even under oath in court. Confidentiality is mandated in the USA by HIPAA laws, specifically the Privacy Rule. Confidentiality is challenged in cases such as the diagnosis of a sexually transmitted disease in a patient who refuses to reveal the diagnosis to a spouse, or in the termination of a pregnancy in an underage patient, without the knowledge of the patient's parents. Many States in the USA have laws governing parental notification in underage abortion[3]

Beneficence

The principle of beneficence expresses the duty of health care providers to be of a benefit to the patient, as well as to take active steps to prevent and to remove harm from the patient.

Bedside rationing

Bedside rationing is defined as when the following conditions exist regarding the physician's actions:[1]

  1. "withhold, withdraw, or fail to recommend a service that, in the physician's best clinical judgment, is in the patient's best medical interests"
  2. "act primarily to promote the financial interests of someone other than the patient (including an organization, society at large, and the physician himself or herself)"
  3. "have control over the use of the beneficial service"

The physician's role in rationing is debated; however, even among proponents of the physician's role there is an emphasis that the physician should not make a rationing decision in isoloation.[2][3]

Autonomy

Justice

Justice in health care is usually defined as a form of fairness,and in medicine it means that when access to health care is limited, then some fair way of allocating those scarce resources must be found. It is generally accepted that persons who are equals should qualify for equal treatment; for example, Medicare is available to all persons over the age of 65 years. This category of persons is equal with respect to their age, but says nothing about need or other factors about the persons in this category. One of the most controversial issues in modern health care is "who has the right to health care?" Most generally, as a society, do we want to provide some minimum level of health care for all citizens, regardless of ability to pay? More particularly, if scarce resources mean that only some people can be treated, how should they be chosen?

Non-maleficence

The concept of non-maleficence is embodied by the phrase, "first, do no harm," (in Latin, primum non nocere). Physicians must not prescribe medications they know to be harmful. American physicians interpret this to exclude the practice of euthanasia, but not all concur. For example, Dr Jack Kevorkian was convicted of second-degree homicide in Michigan in 1998 after demonstrating active euthanasia on the TV news show 60 Minutes.[4] Dr Kekorvian, who claims that he participated in at least 130 assisted suicides, was released in January 2007 after eight years in prison.

Non-maleficence is a legally definable concept. Violation of non-maleficence is the subject of medical malpractice litigation.

Double effect

Some interventions undertaken by physicians can have a beneficial outcome while also potentially doing harm, a combination known as the "double effect." One example is the use of morphine in the dying patient: morphine can ease the pain and suffering of the patient, while simultaneously hastening the patient's demise by suppressing the respiratory drive.

The concept was first formulated, in a more general ethical context, by Thomas Aquinas.

Importance of communication

Many "ethical conflicts" can be traced back to a lack of communication. Communication breakdowns between patients and their healthcare team, between family members, or between members of the medical community, can all lead to disagreements and strong feelings. These breakdowns should be remedied, and many apparently insurmountable "ethical" problems can be solved with open communication.

Ethics committees

Often, simple communication is not enough to resolve a conflict, and a hospital ethics committee, comprised of heath care professionals, clergy, and lay people, must convene to decide a complex matter.

Cultural concerns

Cultural differences can create difficult medical ethics problems. Some cultures have spiritual or magical theories about the origins of disease, for example, and reconciling these beliefs with the tenets of Western medicine can be difficult.

Truth-telling

Some cultures do not place a great emphasis on informing the patient of the diagnosis, especially when cancer is the diagnosis. Even American culture did not emphasize truth-telling in a cancer case until the 1970's. In American medicine, the principle of informed consent takes precedence over other ethical values, and patients are usually at least asked whether they want to know the diagnosis.

Conflicts of interest

For more information, see: Conflict of interest.

"A physician shall, while caring for a patient, regard responsibility to the patient as paramount." Article VIII of the AMA Principles of medical ethics

Physicians should not allow a conflict of interest to influence medical judgment. In some cases, conflicts are hard to avoid, and doctors have a responsibility to avoid entering such situations.

Futility

Advanced directives include living wills and durable powers of attorney for healthcare. Often, these directives document the "expressed wishes" of the patient, and this provides a framework to guide family members and health care professionals in decisionmaking when the patient is incapacitated. Undocumented expressed wishes can also help guide decisionmaking, in the absence of advanced directives. "Substituted judgement" is the concept that a family member can give consent for treatment if the patient is unable (or unwilling) to give consent himself. The key question for the decisionmaking surrogate is not, "What would you like to do," but "What do you think the patient would want in this situation." Courts in the USA have supported family's arbitrary definitions of futility to include simple biological survival, as in the case of "Baby K". [4]

  • Baby Doe Law Establishes state protection for a disabled child's right to life, ensuring that this right is protected even over the wishes of parents or guardians in cases where they want to withhold treatment.

References

  1. Ubel PA, Goold S (January 1997). "Recognizing bedside rationing: clear cases and tough calls". Ann. Intern. Med. 126 (1): 74–80. PMID 8992926[e]
  2. Pearson SD (July 2000). "Caring and cost: the challenge for physician advocacy". Ann. Intern. Med. 133 (2): 148–53. PMID 10896641[e]
  3. Strech D, Synofzik M, Marckmann G (February 2008). "How physicians allocate scarce resources at the bedside: a systematic review of qualitative studies". J Med Philos 33 (1): 80–99. DOI:10.1093/jmp/jhm007. PMID 18420552. Research Blogging.
  4. Baby K, who was born on October 13 1992, was diagnosed prenatally as being anencephalic (with minimal development of brain tissue). This condition is untreatable, and infants usually survive only a few weeks. Despite medical advice, the mother carried Baby K to term. At her mother's insistence, Baby K was intubated and placed on mechanical ventilation. In conjunction with an ethics committee, the physicians recommended a do not resuscitate order, but her mother rejected the recommendation, and the infant eventually was weaned off of the ventilator. In the following months, Baby K was readmitted several times for respiratory distress and apnea. At 6 months of age, a tracheostomy was performed, and the hospital then filed a motion in federal court for appointment of a guardian and a declaration that the hospital could provide only palliative care. The appointed guardian agreed that aggressive treatment should be stopped, but the district court ruled that the hospital was legally obliged to provide ventilator treatment to Baby K. On February 10, 1994, the Appeals court ruled that the hospital was not authorized to decline to provide stabilizing treatment, which it considered ethically inappropriate, to this anencephalic infant or to any patient presenting with an emergency condition. Baby K spent many months in intensive care, and died of cardiac arrest in April 1995.[1]

External links

  1. Lois Snyder for the American College of Physicians Ethics, Professionalism, and Human Rights Committee. (2011) American College of Physicians Ethics Manual: Sixth Edition