BRCA1 gene: Difference between revisions
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In [[physiology]], '''BRCA1 gene''' ('''BRCA-1 gene''') is "a [[tumor suppressor gene]] located on human chromosome 17 at locus 17q21. Mutations of this gene are associated with the formation of familial [[breast cancer|breast]] and [[ovarian cancer|ovarian]] cancer. It encodes a large, nuclear protein that is a component of DNA repair pathways."<ref>{{MeSH}}</ref> | In [[physiology]], '''BRCA1 gene''' ('''BRCA-1 gene''') is "a [[tumor suppressor gene]] located on human chromosome 17 at locus 17q21. Mutations of this gene are associated with the formation of familial [[breast cancer|breast]] and [[ovarian cancer|ovarian]] cancer. It encodes a large, nuclear protein that is a component of DNA repair pathways."<ref>{{MeSH}}</ref> | ||
Women who have BRCA1 or [[BRCA2 gene]] | Women who have BRCA1 or [[BRCA2 gene]] mutations, especially if there is a familial history of [[breast cancer]], may be candidates for prophylactic [[mastectomy]]. <ref>{{citation | ||
| journal = J Natl Cancer Inst | | journal = J Natl Cancer Inst | ||
| volume 93 | issue = 21 | | volume=93 | issue = 21 | ||
| pages = 1633-1637 | | pages = 1633-1637 | ||
| author = Hartmann LC ''et al.'' | | author = Hartmann LC ''et al.'' | ||
| Line 11: | Line 11: | ||
| url = http://jnci.oxfordjournals.org/cgi/content/full/93/21/1633}}</ref> | | url = http://jnci.oxfordjournals.org/cgi/content/full/93/21/1633}}</ref> | ||
==References== | ==References== | ||
<references/> | <references/>[[Category:Suggestion Bot Tag]] | ||
Latest revision as of 11:00, 15 July 2024
In physiology, BRCA1 gene (BRCA-1 gene) is "a tumor suppressor gene located on human chromosome 17 at locus 17q21. Mutations of this gene are associated with the formation of familial breast and ovarian cancer. It encodes a large, nuclear protein that is a component of DNA repair pathways."[1]
Women who have BRCA1 or BRCA2 gene mutations, especially if there is a familial history of breast cancer, may be candidates for prophylactic mastectomy. [2]
References
- ↑ Anonymous (2024), BRCA1 gene (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Hartmann LC et al., "Efficacy of Bilateral Prophylactic Mastectomy in BRCA1 and BRCA2 Gene Mutation Carriers", J Natl Cancer Inst 93 (21): 1633-1637