Net efficacy adjusted for risk: Difference between revisions

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In [[statistics]], '''net efficacy adjusted for risk (NEAR)''' is a measure that combines measure of efficacy and risk into a single metric.<ref name="pmid18974868">{{cite journal| author=Boada JN, Boada C, García-Sáiz M, García M, Fernández E, Gómez E| title=Net efficacy adjusted for risk (NEAR): a simple procedure for measuring risk:benefit balance. | journal=PLoS One | year= 2008 | volume= 3 | issue= 10 | pages= e3580 | pmid=18974868 | doi=10.1371/journal.pone.0003580 | pmc=PMC2570485 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18974868  }} </ref><ref name="pmid19708816">{{cite journal| author=Boada J, Boada C, Garcia MM, Rodriguez C, Garcia M, Fernandez E| title=Net efficacy adjusted for risk: further developments. | journal=Expert Opin Drug Saf | year= 2009 | volume= 8 | issue= 6 | pages= 649-54 | pmid=19708816 | doi=10.1517/14740330903241576 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19708816  }} </ref> For example, the [[relative risk]] of efficacy can be combined with the [[relative risk]] for drug toxicity into a single NEAR RR. Alternatively, the [[odds ratio]] of efficacy can be combined with the [[odds ratio]] for drug toxicity into a single NEAR OR.  
In [[statistics]], '''net efficacy adjusted for risk (NEAR)''' is a measure that combines measure of efficacy and risk into a single metric.<ref name="pmid18974868">{{cite journal| author=Boada JN, Boada C, García-Sáiz M, García M, Fernández E, Gómez E| title=Net efficacy adjusted for risk (NEAR): a simple procedure for measuring risk:benefit balance. | journal=PLoS One | year= 2008 | volume= 3 | issue= 10 | pages= e3580 | pmid=18974868 | doi=10.1371/journal.pone.0003580 | pmc=PMC2570485 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18974868  }} </ref><ref name="pmid19708816">{{cite journal| author=Boada J, Boada C, Garcia MM, Rodriguez C, Garcia M, Fernandez E| title=Net efficacy adjusted for risk: further developments. | journal=Expert Opin Drug Saf | year= 2009 | volume= 8 | issue= 6 | pages= 649-54 | pmid=19708816 | doi=10.1517/14740330903241576 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19708816  }} </ref> For example, the [[relative risk]] of efficacy can be combined with the [[relative risk]] for drug toxicity into a single NEAR RR. Alternatively, the [[odds ratio]] of efficacy can be combined with the [[odds ratio]] for drug toxicity into a single NEAR OR.  


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:<math>\mbox{Net efficacy adjusted for risk (NEAR OR)} =\left (\frac{a_1 * S_2}{a_2 * S_1}\right)</math>
:<math>\mbox{Net efficacy adjusted for risk (NEAR OR)} =\left (\frac{a_1 * S_2}{a_2 * S_1}\right)</math>


The 95% [[confidence interval]]s can be calculated by the method of Boada.<ref name="pmid18974868">{{cite journal| author=Boada JN, Boada C, García-Sáiz M, García M, Fernández E, Gómez E| title=Net efficacy adjusted for risk (NEAR): a simple procedure for measuring risk:benefit balance. | journal=PLoS One |year= 2008 | volume= 3 | issue= 10 | pages= e3580 | pmid=18974868 | doi=10.1371/journal.pone.0003580 | pmc=PMC2570485 |url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18974868  }} </ref>
The 95% [[confidence interval]]s can be calculated by the method of Boada.<ref name="pmid18974868"/>


==References==
==References==
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In statistics, net efficacy adjusted for risk (NEAR) is a measure that combines measure of efficacy and risk into a single metric.[1][2] For example, the relative risk of efficacy can be combined with the relative risk for drug toxicity into a single NEAR RR. Alternatively, the odds ratio of efficacy can be combined with the odds ratio for drug toxicity into a single NEAR OR.

2×2 table combining efficacy and safety results of a theoretical controlled randomized clinical trial.
Re-arrangement of results from typical two-by-two table for calculating NEAR RR or NEAR OR.

Using the second table, let b1+c1+d1 = S1 and b2+c2+d2 = S2. Then

The 95% confidence intervals can be calculated by the method of Boada.[1]

References

  1. ↑ 1.0 1.1 Boada JN, Boada C, García-Sáiz M, García M, Fernández E, Gómez E (2008). "Net efficacy adjusted for risk (NEAR): a simple procedure for measuring risk:benefit balance.". PLoS One 3 (10): e3580. DOI:10.1371/journal.pone.0003580. PMID 18974868. PMC PMC2570485. Research Blogging.
  2. ↑ Boada J, Boada C, Garcia MM, Rodriguez C, Garcia M, Fernandez E (2009). "Net efficacy adjusted for risk: further developments.". Expert Opin Drug Saf 8 (6): 649-54. DOI:10.1517/14740330903241576. PMID 19708816. Research Blogging.
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