Osteoarthritis: Difference between revisions
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A [[meta-analysis]] of [[randomized controlled | A [[meta-analysis]] of [[randomized controlled trial]]s found no benefit from [[chondroitin]].<ref name="pmid17438317">{{cite journal |author=Reichenbach S, Sterchi R, Scherer M, ''et al'' |title=Meta-analysis: chondroitin for osteoarthritis of the knee or hip |journal=Ann. Intern. Med. |volume=146 |issue=8 |pages=580-90 |year=2007 |pmid=17438317 |doi=}}</ref> | ||
====Glucosamine==== | ====Glucosamine==== | ||
Revision as of 23:12, 13 December 2007
Diagnosis
Signs and symptoms
Knee osteoarthritis
Osteoarthritis of the knees is associated with buckling, or sudden giving way, of the knees.[1] This is more likely if the quadriceps muscle is weak.
A screening survey is positive if any one of the following is answered yes:[1]
- During the last 4 weeks, have you had knee pain on most days?
- During the last 4 weeks, have you had knee pain while climbing down stairs or walking down slopes?
- During the last 4 weeks, have you had swelling in one or both knees?
- Do you have knee OA? (If you do, was the diagnosis made by a rheumatologist or a general practitioner?)
- sensitivity = 87%
- specificity = 92%
Using the prevalence of disease in this study, the predictive values are:
- positive predictive value = 51%
- negative predictive value = 98%
Hip osteoarthritis
A screening survey is positive if any one of the following is answered yes:[1]
- During the last 4 weeks, have you had hip pain (groin or upper thigh) on most days?
- During the last 4 weeks, have you had hip pain while climbing down stairs or walking down slopes?
- During the last 4 weeks, have you noticed any limitation in the range of motion of one or both hips?
- Do you have hip osteoarthritis? (If you do, was the diagnosis made by a rheumatologist or a general practitioner?)
- sensitivity = 93%
- specificity = 95%
Using the prevalence of disease in this study (5% to 8%), the predictive values are:
- positive predictive value = 56%
- negative predictive value = 99%
Treatment
Medications
Acetaminophen
A randomized controlled trial comparing acetaminophen to ibuprofen in x-ray proven mild to moderate osteoarthritis of the hip or knee found that equal benefit.[2] However, acetaminophen at a dose of 4 grams per day can increase liver function tests.[3]
Supplements
Chondroitin
A meta-analysis of randomized controlled trials found no benefit from chondroitin.[4]
Glucosamine
A molecule derived from glucosamine is used by the body to make some of the components of cartilage and synovial fluid. Supplemental glucosamine may improve symptoms of OA and delay its progression.[5] However, a large study suggests that glucosamine is not effective in treating OA of the knee.[6] A subsequent meta-analysis that includes this trial concluded that glucosamine hydrochloride is not effective and that the effect of glucosamine sulfate is uncertain.[7]
Prognosis
Among patients presenting with hip pain to their general practitioner, the rates of total hip replacement are:[8]
- 12% of patients at 3 years
- 22% after 6 years
Predictors of the need for a total hip replacement are:[8]
- age >/=60 years, morning stiffness
- pain in the groin/medial thigh
- decreased extension/adduction
- painful internal rotation
- body mass index </=30 kg/m(2)
- Kellgren/Lawrence grade of 2 or higher
References
- ↑ 1.0 1.1 1.2 Felson, David T., Jingbo Niu, Christine McClennan, Burton Sack, Piran Aliabadi, David J. Hunter, et al. 2007. Knee Buckling: Prevalence, Risk Factors, and Associated Limitations in Function. Ann Intern Med 147, no. 8 (October 16): 534-540. http://www.annals.org/cgi/content/abstract/147/8/534 (accessed October 16, 2007). Cite error: Invalid
<ref>tag; name "pmidpending" defined multiple times with different content Cite error: Invalid<ref>tag; name "pmidpending" defined multiple times with different content - ↑ Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI (1991). "Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee". N. Engl. J. Med. 325 (2): 87-91. PMID 2052056. [e]
- ↑ Watkins PB, Kaplowitz N, Slattery JT, et al (2006). "Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: a randomized controlled trial". JAMA 296 (1): 87-93. DOI:10.1001/jama.296.1.87. PMID 16820551. Research Blogging.
- ↑ Reichenbach S, Sterchi R, Scherer M, et al (2007). "Meta-analysis: chondroitin for osteoarthritis of the knee or hip". Ann. Intern. Med. 146 (8): 580-90. PMID 17438317. [e]
- ↑ Poolsup N, Suthisisang C, Channark P, Kittikulsuth W (2005). "Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials". The Annals of pharmacotherapy 39 (6): 1080-7. DOI:10.1345/aph.1E576. PMID 15855241. Research Blogging.
- ↑ McAlindon T, Formica M, LaValley M, Lehmer M, Kabbara K. Effectiveness of glucosamine for symptoms of knee osteoarthritis: Results from an internet-based randomized double-blind controlled trial. Am J Med 2004; 117:643-9. PMID 15501201.
- ↑ Vlad SC, Lavalley MP, McAlindon TE, Felson DT (2007). "Glucosamine for pain in osteoarthritis: Why do trial results differ?" 56 (7): 2267-2277. DOI:10.1002/art.22728. PMID 17599746. Research Blogging.
- ↑ 8.0 8.1 Lievense AM, Koes BW, Verhaar JA, Bohnen AM, Bierma-Zeinstra SM (2007). "Prognosis of hip pain in general practice: A prospective followup study". Arthritis Rheum 57 (8): 1368–1374. DOI:10.1002/art.23094. PMID 18050175. Research Blogging.