Hypercholesterolemia: Difference between revisions
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[[Statin]] therapy prevents major vascular events in about 1 of every 24 patients with [[diabetes]] who use the treatment for 5 years if they are similar to the patients in the [[meta-analysis]] by Kearney et al ([[Number needed to treat]] is 24).<ref name="pmid18191683">{{cite journal |author=Kearney PM, Blackwell L, Collins R, ''et al'' |title=Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis |journal=Lancet |volume=371 |issue=9607 |pages=117–25 |year=2008 |pmid=18191683 |doi=10.1016/S0140-6736(08)60104-X}}</ref> | [[Statin]] therapy prevents major vascular events in about 1 of every 24 patients with [[diabetes]] who use the treatment for 5 years if they are similar to the patients in the [[meta-analysis]] by Kearney et al ([[Number needed to treat]] is 24).<ref name="pmid18191683">{{cite journal |author=Kearney PM, Blackwell L, Collins R, ''et al'' |title=Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis |journal=Lancet |volume=371 |issue=9607 |pages=117–25 |year=2008 |pmid=18191683 |doi=10.1016/S0140-6736(08)60104-X}}</ref> | ||
Treating to a goal of LDL-C <u><</u> 70 mg/dl and systolic blood pressure to <u><</u> 115 mm Hg may cause regression of carotid intial media thickness in a [[randomized controlled trial]].<ref> Howard, B. V., Roman, M. J., Devereux, R. B., Fleg, J. L., Galloway, J. M., Henderson, J. A., et al. (2008). Effect of Lower Targets for Blood Pressure and LDL Cholesterol on Atherosclerosis in Diabetes: The SANDS Randomized Trial. JAMA, 299(14), 1678-1689. {{doi|10.1001/jama.299.14.1678}}. | Treating to a goal of LDL-C <u><</u> 70 mg/dl and systolic blood pressure to <u><</u> 115 mm Hg may cause regression of carotid intial media thickness in a [[randomized controlled trial]].<ref> Howard, B. V., Roman, M. J., Devereux, R. B., Fleg, J. L., Galloway, J. M., Henderson, J. A., et al. (2008). Effect of Lower Targets for Blood Pressure and LDL Cholesterol on Atherosclerosis in Diabetes: The SANDS Randomized Trial. JAMA, 299(14), 1678-1689. {{doi|10.1001/jama.299.14.1678}}.</ref> | ||
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==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 08:13, 9 April 2008
Hypercolesterolemia is "a condition with abnormally high levels of cholesterol in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population."[1]
Treatment
Primary prevention
Overall mortality is insignificantly reduced from 6.6% over 4.3 years to 6.1% in patients without prior cardiovascular disease (Number needed to treat, although statistically insignificant, is estimated to be 200).[2]
Secondary prevention
Diabetic patients
Statin therapy prevents major vascular events in about 1 of every 24 patients with diabetes who use the treatment for 5 years if they are similar to the patients in the meta-analysis by Kearney et al (Number needed to treat is 24).[3]
Treating to a goal of LDL-C < 70 mg/dl and systolic blood pressure to < 115 mm Hg may cause regression of carotid intial media thickness in a randomized controlled trial.[4]
References
- ↑ Anonymous. Hypercholesterolemia. National Library of Medicine. Retrieved on 2008-01-18.
- ↑ Thavendiranathan P, Bagai A, Brookhart MA, Choudhry NK (2006). "Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials". Arch. Intern. Med. 166 (21): 2307–13. DOI:10.1001/archinte.166.21.2307. PMID 17130382. Research Blogging.
- ↑ Kearney PM, Blackwell L, Collins R, et al (2008). "Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis". Lancet 371 (9607): 117–25. DOI:10.1016/S0140-6736(08)60104-X. PMID 18191683. Research Blogging.
- ↑ Howard, B. V., Roman, M. J., Devereux, R. B., Fleg, J. L., Galloway, J. M., Henderson, J. A., et al. (2008). Effect of Lower Targets for Blood Pressure and LDL Cholesterol on Atherosclerosis in Diabetes: The SANDS Randomized Trial. JAMA, 299(14), 1678-1689. DOI:10.1001/jama.299.14.1678.