Nelfinavir: Difference between revisions
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'''Nelfinavir''', sometimes abbreviated as '''NFV''' or '''NLF''' and sold under the brand name '''Viracept®''' is a [[protease inhibitor]] used to treat [[HIV]]/[[AIDS]]. Nelfinavir binds to and inhibits the HIV-1 viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in non-infectious, immature viral particles. Its short half-life (3.5-5 hr) and the lack of activity of it major metabolites means that nelfinavir must be taken every 4-5 hours. It most often used in combination with two or more anti-HIV drugs. | '''Nelfinavir''', sometimes abbreviated as '''NFV''' or '''NLF''' and sold under the brand name '''Viracept®''' is a [[protease inhibitor]] used to treat [[HIV]]/[[AIDS]]. Nelfinavir binds to and inhibits the HIV-1 viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in non-infectious, immature viral particles. Its short half-life (3.5-5 hr) and the lack of activity of it major metabolites means that nelfinavir must be taken every 4-5 hours. It most often used in combination with two or more anti-HIV drugs. | ||
== Chemistry == | |||
Its chemical name is (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino] | Its chemical name is (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino] | ||
-4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide, and its chemical formula is C<sub>32</sub>H<sub>45</sub>N<sub>3</sub>O<sub>4</sub>S. | -4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide, and its chemical formula is C<sub>32</sub>H<sub>45</sub>N<sub>3</sub>O<sub>4</sub>S. | ||
Revision as of 08:33, 22 March 2008
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| Uses: | HIV | ||||||
| Properties: | protease inhibitor | ||||||
| Hazards: | see drug interactions | ||||||
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Nelfinavir, sometimes abbreviated as NFV or NLF and sold under the brand name Viracept® is a protease inhibitor used to treat HIV/AIDS. Nelfinavir binds to and inhibits the HIV-1 viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in non-infectious, immature viral particles. Its short half-life (3.5-5 hr) and the lack of activity of it major metabolites means that nelfinavir must be taken every 4-5 hours. It most often used in combination with two or more anti-HIV drugs.
Chemistry
Its chemical name is (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino] -4-phenylsulfanylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide, and its chemical formula is C32H45N3O4S.
External Links
- Nelfinavir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Template:MedMaster
- Template:DrugBank