Stavudine: Difference between revisions
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imported>David E. Volk (New page: {{subpages}} right|thumb|150px|{{#ifexist:Template:Stavudine structure.jpg/credit|{{Stavudine structure.jpg/credit}}<br/>|}}Stavudine '''Stavudine''' is...) |
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'''Stavudine''' is a dideoxynucleoside analog (2',3'-Didehydro-3'-deoxythimidine) , [[antiviral drug]] that inhibits [[reverse transcriptase]] and is used to treat against [[HIV]]/[[AIDS]] sold under the brand name '''Zerit®'''. It is in the drug class [[nucleoside reverse transcriptase inhibitor]] (NRTI). The phosphorylated form is the active compound that competes with [[deoxythimidine]] triphosphate (dTTP) for incorporation into the viral DNA and which acts as a DNA chain terminator once so incorporated due to the lack of a 3'-hydroxy group. | '''Stavudine''' is a dideoxynucleoside analog (2',3'-Didehydro-3'-deoxythimidine) , [[antiviral drug]] that inhibits [[reverse transcriptase]] and is used to treat against [[HIV]]/[[AIDS]] sold under the brand name '''Zerit®'''. It is in the drug class [[nucleoside reverse transcriptase inhibitor]] (NRTI). The phosphorylated form is the active compound that competes with [[deoxythimidine]] triphosphate (dTTP) for incorporation into the viral DNA and which acts as a DNA chain terminator once so incorporated due to the lack of a 3'-hydroxy group. | ||
== External links == | |||
* {{DailyMed}} | |||
* Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00649 | |||
Revision as of 18:14, 2 February 2008
Stavudine is a dideoxynucleoside analog (2',3'-Didehydro-3'-deoxythimidine) , antiviral drug that inhibits reverse transcriptase and is used to treat against HIV/AIDS sold under the brand name Zerit®. It is in the drug class nucleoside reverse transcriptase inhibitor (NRTI). The phosphorylated form is the active compound that competes with deoxythimidine triphosphate (dTTP) for incorporation into the viral DNA and which acts as a DNA chain terminator once so incorporated due to the lack of a 3'-hydroxy group.
External links
- Stavudine - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00649