Drug-induced liver injury: Difference between revisions
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In [[gastroenterology]] and [[pharmacology]], '''drug-induced liver injury''', also called '''drug-induced liver disease''' or '''drug-induced hepatoxocity''' is "injury to the liver that is associated with impaired liver function caused by exposure to a drug".<ref name="pmid16481640">{{cite journal |author=Navarro VJ, Senior JR |title=Drug-related hepatotoxicity |journal=N. Engl. J. Med. |volume=354 |issue=7 |pages=731–9 |year=2006 |month=February |pmid=16481640 |doi=10.1056/NEJMra052270 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=16481640&promo=ONFLNS19 |issn=}}</ref> Common causes include [[antibiotic]]s, [[anticonvulsant]]s, and [[psychotropic drug]]s.<ref name="pmid18955056">{{cite journal |author=Chalasani N, Fontana RJ, Bonkovsky HL, ''et al'' |title=Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States |journal=Gastroenterology |volume=135 |issue=6 |pages=1924–34, 1934.e1–4 |year=2008 |month=December |pmid=18955056 |doi=10.1053/j.gastro.2008.09.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S0016-5085(08)01674-0 |issn=}}</ref> | In [[gastroenterology]] and [[pharmacology]], '''drug-induced liver injury''', also called '''drug-induced liver disease''' or '''drug-induced hepatoxocity''' is "injury to the liver that is associated with impaired liver function caused by exposure to a drug".<ref name="pmid16481640">{{cite journal |author=Navarro VJ, Senior JR |title=Drug-related hepatotoxicity |journal=N. Engl. J. Med. |volume=354 |issue=7 |pages=731–9 |year=2006 |month=February |pmid=16481640 |doi=10.1056/NEJMra052270 |url=http://content.nejm.org/cgi/pmidlookup?view=short&pmid=16481640&promo=ONFLNS19 |issn=}}</ref> Common causes include [[antibiotic]]s, [[anticonvulsant]]s, and [[psychotropic drug]]s.<ref name="pmid18955056">{{cite journal |author=Chalasani N, Fontana RJ, Bonkovsky HL, ''et al'' |title=Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States |journal=Gastroenterology |volume=135 |issue=6 |pages=1924–34, 1934.e1–4 |year=2008 |month=December |pmid=18955056 |doi=10.1053/j.gastro.2008.09.011 |url=http://linkinghub.elsevier.com/retrieve/pii/S0016-5085(08)01674-0 |issn=}}</ref> | ||
Revision as of 00:00, 19 February 2009
In gastroenterology and pharmacology, drug-induced liver injury, also called drug-induced liver disease or drug-induced hepatoxocity is "injury to the liver that is associated with impaired liver function caused by exposure to a drug".[1] Common causes include antibiotics, anticonvulsants, and psychotropic drugs.[2]
Patterns of liver injury
Hepatocellular
Cholestatic
Mixed
References
- ↑ Navarro VJ, Senior JR (February 2006). "Drug-related hepatotoxicity". N. Engl. J. Med. 354 (7): 731–9. DOI:10.1056/NEJMra052270. PMID 16481640. Research Blogging.
- ↑ Chalasani N, Fontana RJ, Bonkovsky HL, et al (December 2008). "Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States". Gastroenterology 135 (6): 1924–34, 1934.e1–4. DOI:10.1053/j.gastro.2008.09.011. PMID 18955056. Research Blogging.