Glomerulonephritis: Difference between revisions
imported>Robert Badgett (New page: In medicine, '''glomerulonephritis''', also called '''Bright's Disease''', is "inflammation of the renal glomeruli (kidney glomerulus) that can be classified by the type of glomer...) |
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In [[medicine]], '''glomerulonephritis''', also called '''Bright's Disease''', is "inflammation of the renal glomeruli ([[kidney glomerulus]]) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to [[hematuria]]; [[proteinuria]]; [[hypertension]]; and [[renal insufficiency]].".<ref>{{MeSH}}</ref> | In [[medicine]], '''glomerulonephritis''', also called '''Bright's Disease''', is "inflammation of the renal glomeruli ([[kidney glomerulus]]) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to [[hematuria]]; [[proteinuria]]; [[hypertension]]; and [[renal insufficiency]].".<ref>{{MeSH}}</ref> | ||
==Classification== | |||
===Primary glomerulonephritis=== | |||
===Secondary glomerulonephritis=== | |||
Glomerulonephritis may be secondary to systematic [[vasculitis]] or [[connective tissue disease]]. | |||
==Etiology and Pathology== | |||
Glomerulonephritis is "characterized by intraglomerular inflammation and cellular proliferation associated with hematuria. This definition excludes several important nonproliferative or sclerosing glomerulopathies such as [[membranous glomerulopathy]], [[focal segmental glomerulosclerosis]], and [[diabetic nephropathy]]."<ref name="pmid9744974">{{cite journal| author=Hricik DE, Chung-Park M, Sedor JR| title=Glomerulonephritis. | journal=N Engl J Med | year= 1998 | volume= 339 | issue= 13 | pages= 888-99 | pmid=9744974 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=9744974 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> | |||
Glomerulonephritis may be caused by [[vasculitis]] of small vessels.<ref name="pmid9366584">{{cite journal |author=Jennette JC, Falk RJ |title=Small-vessel vasculitis |journal=N. Engl. J. Med. |volume=337 |issue=21 |pages=1512-23 |year=1997 |pmid=9366584 |doi=|url=http://content.nejm.org/cgi/content/full/337/21/1512}}</ref> | Glomerulonephritis may be caused by [[vasculitis]] of small vessels.<ref name="pmid9366584">{{cite journal |author=Jennette JC, Falk RJ |title=Small-vessel vasculitis |journal=N. Engl. J. Med. |volume=337 |issue=21 |pages=1512-23 |year=1997 |pmid=9366584 |doi=|url=http://content.nejm.org/cgi/content/full/337/21/1512}}</ref> | ||
==Diagnosis== | |||
[[Hematuria]] in glomerulonephritis "is typified by the presence of dysmorphic red cells or red-cell casts in the urine" <ref name="pmid9744974">{{cite journal| author=Hricik DE, Chung-Park M, Sedor JR| title=Glomerulonephritis. | journal=N Engl J Med | year= 1998 | volume= 339 | issue= 13 | pages= 888-99 | pmid=9744974 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=9744974 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref> However, these findeing cannot differentiate proliferative from nonproliferative glomerulopathies.<ref name="pmid9744974"/> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 09:18, 26 February 2010
In medicine, glomerulonephritis, also called Bright's Disease, is "inflammation of the renal glomeruli (kidney glomerulus) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to hematuria; proteinuria; hypertension; and renal insufficiency.".[1]
Classification
Primary glomerulonephritis
Secondary glomerulonephritis
Glomerulonephritis may be secondary to systematic vasculitis or connective tissue disease.
Etiology and Pathology
Glomerulonephritis is "characterized by intraglomerular inflammation and cellular proliferation associated with hematuria. This definition excludes several important nonproliferative or sclerosing glomerulopathies such as membranous glomerulopathy, focal segmental glomerulosclerosis, and diabetic nephropathy."[2]
Glomerulonephritis may be caused by vasculitis of small vessels.[3]
Diagnosis
Hematuria in glomerulonephritis "is typified by the presence of dysmorphic red cells or red-cell casts in the urine" [2] However, these findeing cannot differentiate proliferative from nonproliferative glomerulopathies.[2]
References
- ↑ Anonymous (2024), Glomerulonephritis (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ 2.0 2.1 2.2 Hricik DE, Chung-Park M, Sedor JR (1998). "Glomerulonephritis.". N Engl J Med 339 (13): 888-99. PMID 9744974.
- ↑ Jennette JC, Falk RJ (1997). "Small-vessel vasculitis". N. Engl. J. Med. 337 (21): 1512-23. PMID 9366584. [e]