User:Sekhar Talluri

Associate Professor, Department of Biotechnology, GITAM University, India

Courses taught: Biophysical techniques, Bioinformatics

I obtained my M.Sc. degree in Chemistry from Indian Institute of Technology, Delhi (India) in 1984. Subsequently, I was admitted into the Ph.D. program at Cornell University and obtained a Ph.D from Cornell University in 1993 for the thesis entitled NMR spectroscopic studies of protein unfolding, under the guidance of Prof. Scheraga. Afterwards, I joined Prof. Wagner's group in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School in 1993 (initially Dr. J.Hoch from the Rowland Institute of Science was a coguide). After completion of my postdoctoral training, I returned to India. I have been teaching in the Department of Biotechnology in GITAM University since 1998 (at the time of my joining it was referred to as GITAM college).

My contributions

Biophysical techniques (1)  NMR spectroscopy

Nuclear Overhauser effect  Chemical and magnetic equivalence  NMR instrumentation  Quantum fluids (def)  Quantum computing - (def)  Metabonomics (def)  Magnetogyric ratio (def)  Magnetically equivalent

Legend: (Approved)   (Status 1)   (Status 2)   (Status 3)   (External) (Nominated for approval)    

Books

S.Talluri, J.S.R.Murthy and A.Liwo. "Structural Bioinformatics" Chapter 4, pages 45-90, in Fundamentals of Bioinformatics. Edited by Irfan A. Khan & Atiya Khanum. Ukaaz publishers. (2002).

Publications

1. S. Talluri, G. T. Montelione, G. van Duyne, L. Piela, J. Clardy and H. A. Scheraga "Conformational properties of 2,4-Methanoproline in peptides: Evidence for 2,4-Methanopyrrolidine asymmetry based on solid-state X-ray crystallography, 1H-NMR in aqueous solution and CNDO/2 conformational energy calculations." Journal of the American Chemical Society, 109, 4473 (1987).

2. S. Talluri and H. A. Scheraga. "COSY with in-phase cross peaks" Journal of Magnetic Resonance, 86, 1 (1990).

3. S. Talluri and H. A. Scheraga "Amide H/D exchange in the thermal transition of bovine pancreatic Ribonuclease A" Biochemical and Biophysical Research Communications, 172, 800 (1990)

4. C. M. Falcomer, Y. C. Meinwald, I. Choudhary, S. Talluri, P.W.Millburn, J.C.Clardy and H. A. Scheraga "Chain reversals in model peptides: Studies of cystine-containing cyclic peptides. Conformational energies of cyclization of tetrapeptides of sequence Ac-Cys-Pro-X-Cys-NHMe." Journal of the American Chemical Society, 114, 4036 (1992).

5. S. Talluri, C. M. Falcomer and H. A. Scheraga "Energetic and structural basis for the preferential formation of the native disulfide loop involving Cys-65 and Cys-72 in synthetic fragments derived from the sequence of Ribonuclease A." Journal of the American Chemical Society, 115, 3041 (1993).

6. S. Talluri, D. M. Rothwarf and H. A. Scheraga. "Structural characterization of a three-disulfide intermediate of Ribonuclease A in both the folding and unfolding pathways." Biochemistry, 33, 10437 (1994).

7. S. Talluri and G. Wagner. "An optimized NOESY-HSQC" Journal of Magnetic Resonance, 112, 200 (1996). Citations(till 2006 in SCI)=109