Metoprolol: Difference between revisions
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In medicine, metoprolol is a [[adrenergic beta-antagonist]] that is a "selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in [[angina]] pectoris, [[hypertension]], or cardiac arrhythmias." It is also used for [[heart failure]].<ref>{{MeSH}}</ref> | In medicine, metoprolol is a [[adrenergic beta-antagonist]] that is a "selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in [[angina]] pectoris, [[hypertension]], or cardiac arrhythmias." It is also used for [[heart failure]].<ref>{{MeSH}}</ref> | ||
==History== | |||
Metoprolol tartrate was developed by Novartis and received approval in the [[United States]] August 7, 1978.<ref>[http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName=LOPRESSOR Drugs@FDA]. U S Food and Drug Administration</ref> | |||
==Metabolism== | ==Metabolism== | ||
Revision as of 11:18, 8 January 2009
In medicine, metoprolol is a adrenergic beta-antagonist that is a "selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in angina pectoris, hypertension, or cardiac arrhythmias." It is also used for heart failure.[1]
History
Metoprolol tartrate was developed by Novartis and received approval in the United States August 7, 1978.[2]
Metabolism
It is metabolized by cytochrome P-450 2D6 allele and so may have drug interactions[3] and inherited variations in metabolism.[4]
Dosage
For healthy adults, the starting dose is 25 to 100 mg daily in single or divided doses and the maximum dose is 400 to 450 mg/day.
Efficacy
Metoprolol can benefit patients with heart failure.[5]
External links
The most up-to-date information about Metoprolol and other drugs can be found at the following sites.
- Metoprolol - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Metoprolol - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Metoprolol - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Metoprolol (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Drugs@FDA. U S Food and Drug Administration
- ↑ Onalan O, Cumurcu BE, Bekar L (May 2008). "Complete atrioventricular block associated with concomitant use of metoprolol and paroxetine". Mayo Clin. Proc. 83 (5): 595–9. PMID 18452693. [e]
- ↑ Nozawa T, Taguchi M, Tahara K, et al (November 2005). "Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol". J. Cardiovasc. Pharmacol. 46 (5): 713–20. PMID 16220080. [e]
- ↑ Waagstein F, Bristow MR, Swedberg K, et al (December 1993). "Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group". Lancet 342 (8885): 1441–6. PMID 7902479. [e]