Hemolytic anemia: Difference between revisions
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* Peripheral smear | * Peripheral smear<ref name="pmid16079373">{{cite journal| author=Bain BJ| title=Diagnosis from the blood smear. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 5 | pages= 498-507 | pmid=16079373 | doi=10.1056/NEJMra043442 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16079373 }} </ref> | ||
Autoimmunity: | Autoimmunity: | ||
Revision as of 00:54, 22 December 2014
In hematology, Hemolytic anemia is an "A condition of inadequate circulating red blood cells (anemia) or insufficient hemoglobin due to premature destruction of red blood cells (erythrocytes)."[1]
Classification
One classification is based on whether hemolysis occurs intravascularly or extravascularly. Another classification is whether the erythrocytes are intrinsically normal:[2]
Hemolytic anemia associated with normal red cells
- Autoimmune hemolytic anemia
- Direct antiglobulin ("Coombs") test-negative
- Direct antiglobulin ("Coombs") test-positive
- Cold agglutinin disease[3]
- Complement-induced lysis
- Microangiopathic hemolytic anemia. Includes Thrombotic thrombocytopenic purpura.
- Others
Hemolytic anemia associated with abnormal red cells
- Hemoglobinopathies. Includes Sickle cell anemia.
- Metabolic deficiency
- Erythrocyte membrane abnormality. Includes Hereditary spherocytosis.
- Others
Diagnosis
Hemolysis
- Haptoglobin's role in diagnosis has been reviewed.[4] Its accuracy is:[5]
- Sensitivity 83%
- Specificity 96%
- Lactate dehydrogenase
- Dark urine
- Reticulocyte count
- Peripheral smear[6]
Autoimmunity:
- Red-blood-cell-bound immunoglobulin G[7]
- Coombs' test, using the direct method, may have 97% sensitivity for detecting warm antibodies.[8][9]
Microangiopathic hemolytic anemia
- Platelet count
- ADAMTS13 protein activity and inhibitor (von Willebrand factor-degrading protease)[10]
References
- ↑ Anonymous (2024), Hemolytic anemia (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Wright DE, Rosovsky RP, Platt MY (2013). "Case records of the Massachusetts General Hospital. Case 36-2013. A 38-year-old woman with anemia and thrombocytopenia.". N Engl J Med 369 (21): 2032-43. DOI:10.1056/NEJMcpc1215972. PMID 24256382. Research Blogging.
- ↑ Berentsen S, Tjønnfjord GE (2012). "Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia.". Blood Rev 26 (3): 107-15. DOI:10.1016/j.blre.2012.01.002. PMID 22330255. Research Blogging.
- ↑ Shih AW, McFarlane A, Verhovsek M (2014). "Haptoglobin testing in hemolysis: measurement and interpretation.". Am J Hematol 89 (4): 443-7. PMID 24809098. [e]
- ↑ Marchand A, Galen RS, Van Lente F (1980). "The predictive value of serum haptoglobin in hemolytic disease.". JAMA 243 (19): 1909-11. PMID 7365971. [e]
- ↑ Bain BJ (2005). "Diagnosis from the blood smear.". N Engl J Med 353 (5): 498-507. DOI:10.1056/NEJMra043442. PMID 16079373. Research Blogging.
- ↑ Kamesaki T, Oyamada T, Omine M, Ozawa K, Kajii E (2009). "Cut-off value of red-blood-cell-bound IgG for the diagnosis of Coombs-negative autoimmune hemolytic anemia.". Am J Hematol 84 (2): 98-101. DOI:10.1002/ajh.21336. PMID 19105232. Research Blogging.
- ↑ Worlledge SM, Blajchman MA (1972). "The autoimmune haemolytic anaemias.". Br J Haematol 23: Suppl:61-9. PMID 4567200. [e]
- ↑ Allgood JW, Chaplin H (1967). "Idiopathic acquired autoimmune hemolytic anemia. A review of forty-seven cases treated from 1955 through 1965.". Am J Med 43 (2): 254-73. PMID 6034957. [e]
- ↑ Kremer Hovinga JA, Vesely SK, Terrell DR, Lämmle B, George JN (2010). "Survival and relapse in patients with thrombotic thrombocytopenic purpura.". Blood 115 (8): 1500-11; quiz 1662. DOI:10.1182/blood-2009-09-243790. PMID 20032506. Research Blogging.