Hemolytic anemia: Difference between revisions
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==Diagnosis== | ==Diagnosis== | ||
Hemolysis | |||
* [[Haptoglobin]]'s role in diagnosis has been reviewed.<ref name="pmid24809098">{{cite journal| author=Shih AW, McFarlane A, Verhovsek M| title=Haptoglobin testing in hemolysis: measurement and interpretation. | journal=Am J Hematol | year= 2014 | volume= 89 | issue= 4 | pages= 443-7 | pmid=24809098 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24809098 }} </ref> Its accuracy is:<ref name="pmid7365971">{{cite journal| author=Marchand A, Galen RS, Van Lente F| title=The predictive value of serum haptoglobin in hemolytic disease. | journal=JAMA | year= 1980 | volume= 243 | issue= 19 | pages= 1909-11 | pmid=7365971 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7365971 }} </ref> | * [[Haptoglobin]]'s role in diagnosis has been reviewed.<ref name="pmid24809098">{{cite journal| author=Shih AW, McFarlane A, Verhovsek M| title=Haptoglobin testing in hemolysis: measurement and interpretation. | journal=Am J Hematol | year= 2014 | volume= 89 | issue= 4 | pages= 443-7 | pmid=24809098 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24809098 }} </ref> Its accuracy is:<ref name="pmid7365971">{{cite journal| author=Marchand A, Galen RS, Van Lente F| title=The predictive value of serum haptoglobin in hemolytic disease. | journal=JAMA | year= 1980 | volume= 243 | issue= 19 | pages= 1909-11 | pmid=7365971 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7365971 }} </ref> | ||
** [[Sensitivity and specificity|Sensitivity]] 83% | ** [[Sensitivity and specificity|Sensitivity]] 83% | ||
** [[Sensitivity and specificity|Specificity]] 96% | ** [[Sensitivity and specificity|Specificity]] 96% | ||
* [[Lactate dehydrogenase]] | * [[Lactate dehydrogenase]] | ||
* Dark urine | |||
Autoimmunity: | |||
* Red-blood-cell-bound immunoglobulin G<ref name="pmid19105232">{{cite journal| author=Kamesaki T, Oyamada T, Omine M, Ozawa K, Kajii E| title=Cut-off value of red-blood-cell-bound IgG for the diagnosis of Coombs-negative autoimmune hemolytic anemia. | journal=Am J Hematol | year= 2009 | volume= 84 | issue= 2 | pages= 98-101 | pmid=19105232 | doi=10.1002/ajh.21336 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19105232 }} </ref> | |||
* [[Coombs' test]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 00:19, 22 December 2014
In hematology, Hemolytic anemia is an "A condition of inadequate circulating red blood cells (anemia) or insufficient hemoglobin due to premature destruction of red blood cells (erythrocytes)."[1]
Classification
One classification is based on whether hemolysis occurs intravascularly or extravascularly. Another classification is whether the erythrocytes are intrinsically normal:[2]
Hemolytic anemia associated with normal red cells
- Autoimmune hemolytic anemia
- Direct antiglobulin ("Coombs") test-negative
- Direct antiglobulin ("Coombs") test-positive
- Complement-induced lysis
- Microangiopathic hemolytic anemia. Includes Thrombotic thrombocytopenic purpura.
- Others
Hemolytic anemia associated with abnormal red cells
- Hemoglobinopathies. Includes Sickle cell anemia.
- Metabolic deficiency
- Erythrocyte membrane abnormality. Includes Hereditary spherocytosis.
- Others
Diagnosis
Hemolysis
- Haptoglobin's role in diagnosis has been reviewed.[3] Its accuracy is:[4]
- Sensitivity 83%
- Specificity 96%
- Lactate dehydrogenase
- Dark urine
Autoimmunity:
- Red-blood-cell-bound immunoglobulin G[5]
- Coombs' test
References
- ↑ Anonymous (2024), Hemolytic anemia (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Wright DE, Rosovsky RP, Platt MY (2013). "Case records of the Massachusetts General Hospital. Case 36-2013. A 38-year-old woman with anemia and thrombocytopenia.". N Engl J Med 369 (21): 2032-43. DOI:10.1056/NEJMcpc1215972. PMID 24256382. Research Blogging.
- ↑ Shih AW, McFarlane A, Verhovsek M (2014). "Haptoglobin testing in hemolysis: measurement and interpretation.". Am J Hematol 89 (4): 443-7. PMID 24809098. [e]
- ↑ Marchand A, Galen RS, Van Lente F (1980). "The predictive value of serum haptoglobin in hemolytic disease.". JAMA 243 (19): 1909-11. PMID 7365971. [e]
- ↑ Kamesaki T, Oyamada T, Omine M, Ozawa K, Kajii E (2009). "Cut-off value of red-blood-cell-bound IgG for the diagnosis of Coombs-negative autoimmune hemolytic anemia.". Am J Hematol 84 (2): 98-101. DOI:10.1002/ajh.21336. PMID 19105232. Research Blogging.