Drug-induced liver injury
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In gastroenterology and pharmacology, drug-induced liver injury, also called drug-induced liver disease or drug-induced hepatoxocity is "injury to the liver that is associated with impaired liver function caused by exposure to a drug".[1]
Large case series have been published. In one series, common causes include antibiotics, anticonvulsants, and psychotropic drugs.[2] In a second series, common causes included isoniazid, sulfa antibiotics, nitrofurantoin, phenytoin, Non-steroidal anti-inflammatory agents, hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins), propylthiouracil, complementary and alternative medicines, and illicit drugs.[3]
Patterns of liver injury
Hepatocellular
Cholestatic
Mixed
References
- ↑ Navarro VJ, Senior JR (February 2006). "Drug-related hepatotoxicity". N. Engl. J. Med. 354 (7): 731–9. DOI:10.1056/NEJMra052270. PMID 16481640. Research Blogging.
- ↑ Chalasani N, Fontana RJ, Bonkovsky HL, et al (December 2008). "Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States". Gastroenterology 135 (6): 1924–34, 1934.e1–4. DOI:10.1053/j.gastro.2008.09.011. PMID 18955056. Research Blogging.
- ↑ Reuben A, Koch DG, Lee WM, Acute Liver Failure Study Group (2010). "Drug-induced acute liver failure: results of a U.S. multicenter, prospective study.". Hepatology 52 (6): 2065-76. DOI:10.1002/hep.23937. PMID 20949552. Research Blogging.