Zolpidem
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In pharmacology, zolpidem is an agonist of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Zolpidem's pharmacological action is in the category of hypnotics and sedatives. Zolpidem is one of the Z drugs (zopiclone, eszopiclone, zolpidem, and zaleplon).
Efficacy
In treating persistent insomnia in adults, 6 weeks of zolpidem 10 mg nightly along with weekly sessions of cognitive behavioral therapy followed by 6 months of monthly sessions and no medications yielded the most remission of insomnia in a randomized controlled trial.[1]
In geriatrics, the benefits of zolpidem to not clearly exceed the drug toxicity.[2][3]
More Information
- The most up-to-date information about Zolpidem and other drugs can be found at the following sites.
- Zolpidem - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Zolpidem - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Zolpidem - Detailed information from DrugBank.
References
- ↑ Morin CM, Vallières A, Guay B, Ivers H, Savard J, Mérette C et al. (2009). "Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia: a randomized controlled trial.". JAMA 301 (19): 2005-15. DOI:10.1001/jama.2009.682. PMID 19454639. Research Blogging.
- ↑ Glass J, Lanctôt KL, Herrmann N, Sproule BA, Busto UE (2005). "Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits.". BMJ 331 (7526): 1169. DOI:10.1136/bmj.38623.768588.47. PMID 16284208. PMC PMC1285093. Research Blogging. Review in: ACP J Club. 2006 Jul-Aug;145(1):14 Review in: Evid Based Med. 2006 Aug;11(4):110 Review in: Evid Based Nurs. 2006 Jul;9(3):87
- ↑ Nowell PD, Mazumdar S, Buysse DJ, Dew MA, Reynolds CF, Kupfer DJ (1997 Dec 24-31). "Benzodiazepines and zolpidem for chronic insomnia: a meta-analysis of treatment efficacy.". JAMA 278 (24): 2170-7. PMID 9417012.