Hemolytic anemia
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In hematology, Hemolytic anemia is an "A condition of inadequate circulating red blood cells (anemia) or insufficient hemoglobin due to premature destruction of red blood cells (erythrocytes)."[1]
Classification
One classification is based on whether hemolysis occurs intravascularly or extravascularly. Another classification is whether the erythrocytes are intrinsically normal:[2]
Hemolytic anemia associated with normal red cells
- Autoimmune hemolytic anemia
- Direct antiglobulin ("Coombs") test-negative
- Direct antiglobulin ("Coombs") test-positive
- Complement-induced lysis
- Microangiopathic hemolytic anemia. Includes Thrombotic thrombocytopenic purpura.
- Others
Hemolytic anemia associated with abnormal red cells
- Hemoglobinopathies. Includes Sickle cell anemia.
- Metabolic deficiency
- Erythrocyte membrane abnormality. Includes Hereditary spherocytosis.
- Others
Diagnosis
References
- ↑ Anonymous (2024), Hemolytic anemia (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Wright DE, Rosovsky RP, Platt MY (2013). "Case records of the Massachusetts General Hospital. Case 36-2013. A 38-year-old woman with anemia and thrombocytopenia.". N Engl J Med 369 (21): 2032-43. DOI:10.1056/NEJMcpc1215972. PMID 24256382. Research Blogging.
- ↑ Marchand A, Galen RS, Van Lente F (1980). "The predictive value of serum haptoglobin in hemolytic disease.". JAMA 243 (19): 1909-11. PMID 7365971. [e]