Tenofovir

tenofovir
IUPAC name: see chemistry section Synonyms: TDF, PMPA Formula: C9H14N5O4P
Uses:	HIV/AIDS & Hep. B
Properties:	RT inhibitor, adenosine analog
Hazards:	see drug interactions
Mass (g/mol): CAS #: 287.2123 147127-20-6

Tenofovir is a nucleotide analog reverse transcritase inhibitor (nRTI) antiviral drug used to treat HIV/AIDS and is in clinical trials for treatment of hepatitis B infection. The triphosphate from of the drug competes with the natural DNA nucleotide deoxyadenosine triphosphate (dATP) during DNA formation and it acts as a DNA chain terminator once incorporated because it lacks the normal deoxyribose sugar needed for connecting to the next DNA base.

Chemistry

The IUPAC chemical name for tenofovir is [(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid and it has chemical formula C₉H₁₄N₅O₄P, giving it a molecular mass of 287.2123 g/mol. It is chemically similar to the natural neucleotide adenosine but lacks a ribose sugar unit.

Synonyms and brand names

Synonyms

• Tenofovir disoproxil
• Tenofovir disoproxil fumarate
• D,L-Tenofovir
• TDF
• PMPA

Brand Names

• Apropovir
• Viread

External links

• Tenofovir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
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