Penciclovir/Related Articles
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- See also changes related to Penciclovir, or pages that link to Penciclovir or to this page or whose text contains "Penciclovir".
Penciclovir (PE2) or penciclovirum, is a guanosine analog, antiviral drug used to treat herpesviruses and is the active metabolite of the prodrug famciclovir. It is sold under the brand name Denavir®. The longer half-life of penciclovir triphosphate in herpes-infected cells (10-20 hrs), compared to that of acyclovir (0,7 -1 hr), may be responsible for its ehanced results. The triphosphate form competes with deoxyguanosine triphosphate for incorporation into viral DNA. It only effects DNA synthesis of only those cells infected with herpes simplex virus (HSV).
Parent topics
- Antiviral drug [r]: A chemical that interfers with the replication cycle of viruses. [e]
- Nucleotide analogue [r]: Add brief definition or description
- Herpesvirus [r]: Add brief definition or description
- Herpes simplex virus [r]: One of the herpes, DNA viruses that are important in causing human disease. [e]
- Famciclovir [r]: Antiviral drug used for the treatment of herpes viruses, especially herpes zoster (shingles). [e]
Subtopics
- Deoxyguanosine [r]: Add brief definition or description
- DNA [r]: A macromolecule — chemically, a nucleic acid — that stores genetic information. [e]
- DNA synthesis [r]: Please do not use this term in your topic list, because there is no single article for it. Please substitute a more precise term. See DNA synthesis (disambiguation) for a list of available, more precise, topics. Please add a new usage if needed.
- Acyclovir [r]: An antiviral, anti-metabolite drug, similar to guanine, that acts as a viral DNA chain terminator. [e]