Tenofovir

(CC) Image: David E. Volk
Tenofovir

Tenofovir is a nucleotide analog reverse transcritase inhibitor (nRTI) antiviral drug used to treat HIV/AIDS and is in clinical trials for treatment of hepatitis B infection. The triphosphate from of the drug competes with the natural DNA nucleotide deoxyadenosine triphosphate (dATP) during DNA formation and it acts as a DNA chain terminator once incorporated because it lacks the normal deoxyribose sugar needed for connecting to the next DNA base.

Synonyms and brand names

Synonyms

• Tenofovir disoproxil
• Tenofovir disoproxil fumarate
• D,L-Tenofovir
• TDF
• PMPA

Brand Names

• Apropovir
• Viread

External links

• Tenofovir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00300.txt