Theoretical biology/Bibliography

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A list of key readings about Theoretical biology.
Please sort and annotate in a user-friendly manner. For formatting, consider using automated reference wikification.

Journals focusing on aspects of theoretical biology


  • Aims & Scope: Computational & Mathematical Methods in Medicine (formerly Journal of Theoretical Medicine) seeks to promote genuine interdisciplinary collaboration between those interested in the theoretical and clinical aspects of medicine and to foster and encourage the application of mathematics to problems arising from the biomedical sciences. Areas of interest include gene therapy, cell kinetics, pharmacokinetics, chemotherapy, oncology, developmental biology, wound healing, physiology, heart modelling, cardiovascular and lung dynamics, neurobiology, computational neuroscience, biomechanics, biomedical statistics, image analysis, epidemiology, immunology, time series analysis, extracellular matrix properties and signalling, and tissue engineering. This list is not exclusive and papers in other biomedical disciplines are encouraged, particularly in the emerging areas of multiscale modelling in medicine, systems biology and translational research.


  • Description: An interdisciplinary journal, Theoretical Population Biology presents articles on the theoretical aspects of the biology of populations, particularly in the areas of ecology, genetics, demography, and epidemiology. Primary emphasis is on development of theory, but the journal also presents experimental results directly impinging on theoretical descriptions of populations and the dynamics of populations.
  • Five most downloaded articles, April-June 2008:
  • On analytical approaches to epidemics on networks
  • Game theory and human evolution: A critique of some recent interpretations of experimental games
  • The ideal free distribution: A review and synthesis of the game-theoretic perspective
  • Effects of predation on host-pathogen dynamics in SIR models [SIR model: an epidemiological model, computes theoretically the number of individuals infected contagiously by an illness over time in a closed population]
  • The evolution of strong reciprocity: cooperation in heterogeneous populations


  • Description: Biological Theory: Integrating Development, Evolution, and Cognition is devoted to theoretical advances in the biological and cognitive sciences, with an emphasis on the conceptual integration afforded by evolutionary and developmental approaches. The journal appeals to a wide audience of scientists, social scientists, philosophers and historians of biology.
  • Titles of the ten most downloaded articles (as of November 2008):
  • Do Molecular Clocks Run at All? A Critique of Molecular Systematics (2661 times)
  • Movement Matters: The Contributions of Esther Thelen (732 times)
  • Karl Popper and Lamarckism (494 times)
  • Theoretical Integration, Cooperation, and Theories as Tracking Devices (467 times)
  • Self-Extending Symbiosis: A Mechanism for Increasing Robustness Through Evolution (430 times)
  • Ontogeny, Genetics, and Evolution: A Perspective from Developmental Cognitive Neuroscience (392 times)
  • The Essence of Scientific Theories (368 times)
  • The Heterochronic Evolution of Primate Cognitive Development (363 times)
  • The Developmental-Genetic Toolkit and the Molecular Homology–Analogy Paradox (328 times)
  • Modest Evolutionary Naturalism (316 times)
  • Description: An Open access journal focusing on all aspects of biology and the conceptual modeling required to understand its complexity.
  • Titles of the ten most downloaded articles (as of November 2008):
  • Inflammation: a way to understanding the evolution of portal hypertension (733 times)
  • Analysis of novel geometry-independent method for dialysis access pressure-flow monitoring (555 times)
  • Extracting key information from historical data to quantify the transmission dynamics of smallpox (390 times)
  • Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations (375 times)
  • Mitochondrial concept of leukemogenesis: key role of oxygen-peroxide effects (372 times)
  • Moderate exercise and chronic stress produce counteractive effects on different areas of the brain by acting through various neurotransmitter receptor subtypes: A hypothesis (350 times)
  • Common angiotensin receptor blockers may directly modulate the immune system via VDR, PPAR and CCR2b (333 times)
  • Vasculature deprivation – induced osteonecrosis of the rat femoral head as a model for therapeutic trials (327 times)
  • A mathematical model of glutathione metabolism(324 times)
  • Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary (310 times)