Bisphosphonate
In medicine, bisphosphonates are medications which "contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents."[1]
Bisphosphonates are used to prevent fractures among patients with osteoporosis or low bone mass.
Examples of bisphosphonates include alendronate, risedronate, etidronate, ibandronate, pamidronate, and zoledronic acid.
Adverse effects
Atrial fibrillation may be caused by zoledronic acid.[2]
Osteonecrosis of the jaw was first reported in three patients in 2003; however, the patients were on multiple medications and the authors did not assert that the bisphosphonates that the patients were taking were responsible.[3] A series of 63 patients were reported in 2004 in which the author asserted that biphosphosphonates were causal.[4] A systematic review of published cases was reported in 2006.[5]
References
- ↑ Anonymous (2024), Bisphosphonate (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Black DM, Delmas PD, Eastell R, et al. (May 2007). "Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis". N. Engl. J. Med. 356 (18): 1809–22. DOI:10.1056/NEJMoa067312. PMID 17476007. Research Blogging.
- ↑ Wang J, Goodger NM, Pogrel MA (2003). "Osteonecrosis of the jaws associated with cancer chemotherapy.". J Oral Maxillofac Surg 61 (9): 1104-7. PMID 12966490.
- ↑ Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL (2004). "Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases.". J Oral Maxillofac Surg 62 (5): 527-34. PMID 15122554.
- ↑ Woo SB, Hellstein JW, Kalmar JR (2006). "Narrative [corrected review: bisphosphonates and osteonecrosis of the jaws."]. Ann Intern Med 144 (10): 753-61. PMID 16702591.