Black Death
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The Black Death, also known as the Black Plague, was a devastating pandemic that first struck Europe in the mid-late-14th century (1347–1351), killing between a third and two thirds of Europe's population. Almost simultaneous epidemics occurred across large portions of Asia and the Middle East during the same period, indicating that the European outbreak was actually part of a multi-regional pandemic. Including Middle Eastern lands, India and China, the Black Death killed at least 75 million people. The same disease is thought to have returned to Europe every generation with varying degrees of intensity and fatality until the 1700s.