Disease modifying anti-rheumatic drugs/Related Articles
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Disease modifying anti-rheumatic drugs: Drugs that directly affect the underlying autoimmune processes in rheumatological disease, rather than act simply as analgesics or nonspecific antiinflammatories; they include gold compounds (e.g., aurothioglucose), antimalarials, penicillamine, and monoclonal antibodies against tumor necrosis factor-alpha and other immunochemicals [e]
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Parent topics
- Rheumatology [r]: Medical specialty that deals with the study, diagnosis, and treatment of connective tissue diseases; a subspecialty of internal medicine [e]
- Autoimmune disease [r]: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides. [e]
Subtopics
Drugs
- Antimalarial [r]: Rather than all drugs active against malaria, usually a reference to several synthetic analogues of quinine, with applications against malaria and other parasites, but also as disease modifying anti-rheumatic drugs (DMARD) used as immunomodulators in rheumatology [e]
- Chloroquine [r]: First effective synthetic antimalarial; discovered in Germany and not generally available until after the Second World War [e]
- Hydroxychloroquine [r]: Add brief definition or description
- Pyrimidine synthesis inhibitor [r]: Add brief definition or description
- Leflunomide [r]: A pyrimidine synthesis inhibitor used to treat rheumatoid arthritis. [e]
- Tumor necrosis factor-alpha blockers [r]: Add brief definition or description
- Interleukin-1 blockers [r]: Add brief definition or description
- Azathioprine [r]: An immunosuppressive purine synthesis inhibitor for treating rheumatoid arthritis; formerly a chemotherapy drug. [e]
- Methotrexate [r]: An inhibitor of tetrahydrofolate dehydrogenase, which prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA; it has a wide range of medical applications. [e]
- Cyclosporin [r]: Add brief definition or description
- Minocycline [r]: An antibiotic tetracycline analog that can be used to treat tetracycline-resistant staphylococcus infections. [e]
- Sulfasalazine [r]: A sulfa drug, a derivative of Mesalazine, used primarily as an anti-inflammatory agent in the treatment of inflammatory bowel disease as well as for rheumatoid arthritis. [e]
- Gold-based drugs [r]: Add brief definition or description
- Glucocorticoid [r]: Corticosteroids that affect carbohydrate metabolism, inhibit adrenocorticotropic hormone secretion, and are anti-inflammatory. [e]
- Anti-B cell (CD20) antibody [r]: Add brief definition or description
- Blockers of T cell activation [r]: Add brief definition or description
Diseases
- Rheumatoid arthritis [r]: A chronic, inflammatory autoimmune disorder that causes the immune system to attack the joints. [e]
- Systemic lupus erythematosus [r]: Connective tissue disorder, that primarily affect women of childbearing age, have a variety of clinical forms, and are characterized by red scaly skin lesions. [e]
- Mixed connective tissue disorder [r]: Add brief definition or description