New Delhi metallo-beta-lactamase-1
New Delhi metallo-beta-lactamase-1 enzyme confers bacterial resistance to antibiotics of the carbepenem class, often considered "last resort" drugs for multidrug resistant bacteria.[1] The gene to manufacture it can be horizontally transferred among different species of pathogenic bacteria.
Organisms that produce the enzyme are resistant to virtually all beta-lactam antibiotics except azneotram. [2] These organisms often are also resistant to fluoroquinolones and aminoglycosides.
First reported in Klebsiella pneumoniae, it has been reported in Acinetobacter, Escherichia coli, Citrobacter freundii, Enterobacter cloacae, and Morganella morganii. A number of cases have been found in Britain, Canada and the US in patients that went to India for medical procedures or were treated for emergencies while in India.[3]
References
- ↑ Krishna B (2010 [cited 2010 Sep 14]), "New Delhi metallo-beta-lactamases: A wake-up call for microbiologists", Indian J Med Microbiol [serial online] 28: 265-6.
- ↑ >Nordmann P, Poirel L. (2002), "Emerging carbapenemases in Gram-negative aerobes", Clin Microbiol Infect 8: 321-31
- ↑ "NDM-1 carrying Enterobacteriaceae - worldwide ex India, Pakistan (02)", ProMED Emerging Disease Report, International Society for Infectious Diseases, 14 September 2010