Alcoholic hepatitis: Difference between revisions
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In [[gastroenterology]], '''alcoholic hepatitis''' is "[[inflammation]] of the [[liver]] due to [[alcohol abuse]]. It is characterized by [[necrosis ]]of [[hepatocyte]]s, infiltration by [[neutrophil]]s, and deposit of mallory hyaline bodies. depending on its severity, the inflammatory lesion may be reversible or progress to [[liver cirrhosis]]."<ref>{{MeSH}}</ref><ref | {{TOC|right}} | ||
In [[gastroenterology]], '''alcoholic hepatitis''' is "[[inflammation]] of the [[liver]] due to [[alcohol abuse]]. It is characterized by [[necrosis ]]of [[hepatocyte]]s, infiltration by [[neutrophil]]s, and deposit of mallory hyaline bodies. depending on its severity, the inflammatory lesion may be reversible or progress to [[liver cirrhosis]]."<ref>{{MeSH}}</ref>A practice guideline is available from the American College of Gastroenterology.<ref>{{citation | |||
| url = http://www.acg.gi.org/physicians/guidelines/AlcoholicLiverDisease.pdf | |||
| title = Alcoholic Liver Disease: Proposed Recommendations | |||
| journal = Am J Gastroenterol | year = 2010 | volume = 105 | pages = 14–32 | doi= 10.1038/ajg.2009.593 | date = 10 November 2009}}</ref> | |||
==Treatment== | ==Treatment== | ||
[[Corticosteroid]]s may help in severe cases.<ref name="pmid18363896">{{ | [[Corticosteroid]]s may help in severe cases.<ref name="pmid18363896">{{citation | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=18363896 | doi=10.1111/j.1365-2036.2008.03685.x }} | | author=Rambaldi A, Saconato HH, Christensen E, Thorlund K, Wetterslev J, Gluud C | ||
| title=Systematic review: glucocorticosteroids for alcoholic hepatitis--a Cochrane Hepato-Biliary Group systematic review with meta-analyses and trial sequential analyses of randomized clinical trials. | |||
| journal=Aliment Pharmacol Ther | year= 2008 | volume= 27 | issue= 12 | pages= 1167-78 | |||
| pmid=18363896 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&email=badgett@uthscdsa.edu&retmode=ref&cmd=prlinks&id=18363896 | |||
| doi=10.1111/j.1365-2036.2008.03685.x | |||
}}</ref> | |||
The role of [[pentoxifylline]] is uncertain.<ref name="pmid19821406">{{cite journal| author=Whitfield K, Rambaldi A, Wetterslev J, Gluud C| title=Pentoxifylline for alcoholic hepatitis. | journal=Cochrane Database Syst Rev | year= 2009 | volume= | issue= 4 | pages= CD007339 | pmid=19821406 | The role of [[pentoxifylline]] is uncertain.<ref name="pmid19821406">{{cite journal| author=Whitfield K, Rambaldi A, Wetterslev J, Gluud C| title=Pentoxifylline for alcoholic hepatitis. | journal=Cochrane Database Syst Rev | year= 2009 | volume= | issue= 4 | pages= CD007339 | pmid=19821406 | ||
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==References== | ==References== | ||
{{reflist|2}} | |||
Revision as of 01:25, 10 June 2010
In gastroenterology, alcoholic hepatitis is "inflammation of the liver due to alcohol abuse. It is characterized by necrosis of hepatocytes, infiltration by neutrophils, and deposit of mallory hyaline bodies. depending on its severity, the inflammatory lesion may be reversible or progress to liver cirrhosis."[1]A practice guideline is available from the American College of Gastroenterology.[2]
Treatment
Corticosteroids may help in severe cases.[3]
The role of pentoxifylline is uncertain.[4]
References
- ↑ Anonymous (2024), Alcoholic hepatitis (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ "Alcoholic Liver Disease: Proposed Recommendations", Am J Gastroenterol 105: 14–32, 10 November 2009, DOI:10.1038/ajg.2009.593
- ↑ Rambaldi A, Saconato HH, Christensen E, Thorlund K, Wetterslev J, Gluud C (2008), "Systematic review: glucocorticosteroids for alcoholic hepatitis--a Cochrane Hepato-Biliary Group systematic review with meta-analyses and trial sequential analyses of randomized clinical trials.", Aliment Pharmacol Ther 27 (12): 1167-78, DOI:10.1111/j.1365-2036.2008.03685.x
- ↑ Whitfield K, Rambaldi A, Wetterslev J, Gluud C (2009). "Pentoxifylline for alcoholic hepatitis.". Cochrane Database Syst Rev (4): CD007339. DOI:10.1002/14651858.CD007339.pub2. PMID 19821406. Research Blogging.