Arginine vasopressin receptor 1B: Difference between revisions

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'''Arginine vasopressin receptor 1B''' (AVPR1B, vasopressin 3 receptor) is a [[protein]] that acts as [[receptor]] for [[Vasopressin|arginine vasopressin]]. AVPR1B belongs to the subfamily of [[G-protein coupled receptor]]s. Its activity is mediated by G proteins which stimulate a [[phosphatidylinositol]]-[[calcium]] second messenger system.
'''Arginine vasopressin receptor 1B''' (AVPR1B, vasopressin 3 receptor) is a [[protein]] that acts as [[receptor]] for [[Vasopressin|arginine vasopressin]]. AVPR1B belongs to the subfamily of [[G-protein coupled receptor]]s. Its activity is mediated by G proteins which stimulate a [[phosphatidylinositol]]-[[calcium]] second messenger system.


AVPR1B was initially described as a novel vasopressin receptor located in the [[anterior pituitary]], where it stimulates [[ACTH]] release. Subsequent studies have shown its presence in the brain as well.
AVPR1B was initially described as a novel vasopressin receptor located in the [[anterior pituitary]], where it stimulates [[ACTH]] release<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=6089144&query_hl=4&itool=pubmed_DocSum</ref>, especially in synergism with [[corticotropin releasing factor]]. Subsequent studies have shown its presence in the brain as well<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11250948&query_hl=11&itool=pubmed_docsum</ref>,<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17027167&query_hl=13&itool=pubmed_docsum</ref>.


Inactivation of the Avpr1b in mice (knockout) produces mice with greatly reduced aggression.  These mice also have a reduced ability to recognize recently investigated mice. There is evidence that social motivation or awareness is reduced in these mice.  The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsters and anti-depressant- and anxiety (anxiolytic)-like behaviors in rats.
Inactivation of the Avpr1b in mice (knockout) produces mice with greatly reduced aggression and a reduced ability to recognize recently investigated mice.<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12399951&query_hl=13&itool=pubmed_docsum</ref>.  Interestingly, defensive behavior and predatory behaviors appear to normal in these knockout mice<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17284170&query_hl=13&itool=pubmed_docsum</ref>. There is evidence that social motivation or awareness is reduced in these mice<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15555506&query_hl=13&itool=pubmed_docsum</ref>.  The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsters<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15652395&query_hl=19&itool=pubmed_docsum</ref> and anti-depressant- and anxiety (anxiolytic)-like behaviors in rats<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15867952&query_hl=21&itool=pubmed_docsum</ref>.


AVPR1B is expressed at high levels in ACTH-secreting [[pituitary adenoma]]s as well as in [[bronchial carcinoid]]s responsible for the [[ectopic ACTH syndrome]].
AVPR1B is expressed at high levels in ACTH-secreting [[pituitary adenoma]]s as well as in [[bronchial carcinoid]]s responsible for the [[ectopic ACTH syndrome]]. Various stress-induced elevations of ACTH are blunted in the Avpr1b knockout mouse<ref>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17122081&query_hl=13&itool=pubmed_docsum</ref>.




== References ==
== References ==


*[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=6089144&itool=iconabstr&query_hl=17&itool=pubmed_DocSum Antoni FA, et al., Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor]


*[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12399951&itool=iconabstr&query_hl=8&itool=pubmed_DocSum Wersinger SR, et al., Vasopressin V1b receptor knockout reduces aggressive behavior in male mice]
*[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15867952&itool=iconabstr&query_hl=11&itool=pubmed_docsum Serradeil-Le Gal C, et al., An overview of SSR149415, a selective nonpeptide vasopressin V(1b) receptor antagonist for the treatment of stress-related disorders]
[[Category:G protein coupled receptors]]
[[Category:G protein coupled receptors]]
[[Category:CZ Live]]
[[Category:CZ Live]]
[[Category:Health Sciences Workgroup]]
[[Category:Health Sciences Workgroup]]
[[Category:Biology Workgroup]]
[[Category:Biology Workgroup]]

Revision as of 22:13, 16 February 2007

Arginine vasopressin receptor 1B
Identifiers
Symbol(s) AVPR1B
Entrez 553
OMIM 600264
RefSeq NM_000707
UniProt P47901
Other data
Locus Chr. 1 q32


Arginine vasopressin receptor 1B (AVPR1B, vasopressin 3 receptor) is a protein that acts as receptor for arginine vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.

AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary, where it stimulates ACTH release[1], especially in synergism with corticotropin releasing factor. Subsequent studies have shown its presence in the brain as well[2],[3].

Inactivation of the Avpr1b in mice (knockout) produces mice with greatly reduced aggression and a reduced ability to recognize recently investigated mice.[4]. Interestingly, defensive behavior and predatory behaviors appear to normal in these knockout mice[5]. There is evidence that social motivation or awareness is reduced in these mice[6]. The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsters[7] and anti-depressant- and anxiety (anxiolytic)-like behaviors in rats[8].

AVPR1B is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. Various stress-induced elevations of ACTH are blunted in the Avpr1b knockout mouse[9].


References

  1. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=6089144&query_hl=4&itool=pubmed_DocSum
  2. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=11250948&query_hl=11&itool=pubmed_docsum
  3. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17027167&query_hl=13&itool=pubmed_docsum
  4. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12399951&query_hl=13&itool=pubmed_docsum
  5. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17284170&query_hl=13&itool=pubmed_docsum
  6. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15555506&query_hl=13&itool=pubmed_docsum
  7. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15652395&query_hl=19&itool=pubmed_docsum
  8. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15867952&query_hl=21&itool=pubmed_docsum
  9. ↑ http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17122081&query_hl=13&itool=pubmed_docsum
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