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== '''[[Oxytocin]]''' ==
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'''Oxytocin''' (Greek: "quick birth") is a [[mammal]]ian [[hormone]] that is secreted into the bloodstream from the [[posterior pituitary]] gland, and that is also released into the [[brain]], where it has effects on social behaviors. In pregnant women, it is secreted into the blood during labor in response to distention of the [[cervix]] and it stimulates contractions of the [[uterus]] to facilitate [[childbirth|birth]]. During [[lactation]], oxytocin is secreted in response to stimulation of the [[nipple]]s by the sucking of the infant, and it stimulates milk let-down in the [[mammary gland]]. Oxytocin is also secreted during [[orgasm]] in both sexes; in men it facilitates movement of [[sperm]]. In the brain, it is involved in social recognition, bonding, sexual arousal, reproductive behaviors and appetite regulation, and might be involved in the formation of trust between people. In some species, including rats, oxytocin also promotes sodium excretion ([[natriuresis]]) and inhibits [[sodium appetite]].<ref>Lee HJ ''et al.'' (2009) Oxytocin: the great facilitator of life.
==Footnotes==
''Prog Neurobiol'' 88:127-51. Review. PMID 19482229</ref><ref>Neumann ID (2008) Brain oxytocin: a key regulator of emotional and social behaviours in both females and males ''J Neuroendocrinol'' 20:858-65. Review.
PMID 18601710</ref><ref>Arthur P ''et al.'' (2007) Oxytocin and parturition: a role for increased myometrial calcium and calcium sensitization? ''Front Biosci''  12:619-33. Review. PMID 17127323</ref>
<ref>Caldwell HK, Young WS III (2006) Oxytocin and vasopressin: genetics and behavioral implications. In Lim R. (ed.) ''Handbook of Neurochemistry and Molecular Neurobiology'' 3rd edition, Springer, New York, pp. 573-607. [http://refworks.springer.com/mrw/fileadmin/pdf/Neurochemistry/0387303480C25.PDF 320kb PDF]</ref>
 
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Latest revision as of 10:19, 11 September 2020

Nuclear weapons proliferation is one of the four big issues that have held back worldwide deployment of peaceful nuclear power. This article will address the proliferation questions raised in Nuclear power reconsidered.

As of 2022, countries with nuclear weapons have followed one or both of two paths in producing fissile materials for nuclear weapons: enrichment of uranium to very high fractions of U-235, or extraction of fissile plutonium (Pu-239) from irradiated uranium nuclear reactor fuel. The US forged the way on both paths during its World War II Manhattan Project. The fundamental aspects of both paths are well understood, but both are technically challenging. Even relatively poor countries can be successful if they have sufficient motivation, financial investment, and, in some cases, direct or illicit assistance from more technologically advanced countries.

The International Non-proliferation Regime

The International Atomic Energy Agency (IAEA) has a vigorous program to prevent additional countries from acquiring nuclear weapons. The Treaty on the Non-Proliferation of Nuclear Weapons (NPT) is the cornerstone arrangement under which strategic rivals can trust, by independent international verification, that their rivals are not developing a nuclear weapons threat. The large expense of weapons programs makes it very unlikely that a country would start its own nuclear weapons program, if it knows that its rivals are not so engaged. With some notable and worrying exceptions, this program has been largely successful.

Paths to the Bomb

It is frequently claimed that building a civil nuclear power program adds to the weapons proliferation risk. There is an overlap in the two distinct technologies, after all. To build a bomb, one needs Highly Enriched Uranium (HEU) or weapons-grade plutonium (Pu-239). Existing reactors running on Low Enriched Uranium (LEU, under 5% U-235) or advanced reactors running on High Assay LEU (HALEU,up to 20% U-235) use the same technology that can enrich uranium to very high levels, but configured differently. Enrichment levels and centrifuge configurations can be monitored using remote cameras, on-site inspections, and installed instrumentation -- hence the value of international inspections by the IAEA. Using commercial power reactors as a weapons plutonium source is an extremely ineffective, slow, expensive, and easily detectable way to produce Pu. Besides the nuclear physics issues, refueling pressurized water reactors is both time-consuming and obvious to outside observers. That is why the US and other countries developed specialized Pu production reactors and/or uranium enrichment to produce fissile cores for nuclear weapons.

Future Threats and Barriers

Minimizing the risk of future proliferation in states that want to buy nuclear reactors or fuel might require one or more barriers:
1) Insisting on full transparency for all nuclear activities in buyer states, including monitoring and inspections by the International Atomic Energy Agency (IAEA).
2) Limiting fuel processing to just a few supplier states that already have weapons or are approved by the IAEA.
3) Ensuring that fuel at any stage after initial fabrication has an isotopic composition unsuitable for weapons. "Spiking" the initial fuel with non-fissile isotopes, if necessary.
4) Limiting the types of reactors deployed to buyer states. In general, breeders are less secure than burners. Sealed reactor modules are more secure than reactors with on-site fuel processing.
5) Providing incentives and assurances for buyer states to go along with all of the above.
6) Application of diplomatic pressure, sanctions, and other economic measures to non-compliant states.
7) Agreement that any reactor declared rogue by the IAEA will be "fair game" for any state feeling threatened.

Footnotes