Trimethoprim/Definition

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Trimethoprim [r]: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to pyrimethamine. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by sulfonamides and the trimethoprim-sulfamethoxazole combination is the form most often used. It is sometimes used alone as an antimalarial.

This definition is at least in part based on: Anonymous (2023), Trimethoprim (English). Medical Subject Headings. U.S. National Library of Medicine.