User:Gyorgy Szabadkai

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Gyorgy Szabadkai, MD; PhD

Education, Training and Positions:

1993 M.D. Semmelweis University of Medicine, Budapest, Hungary

2000 Ph.D. in Molecular Cell Biology ‘Generation and Consequences of Ca2+ Signaling in Endocrine Cells’

2000-2003 Postdoctoral research fellow, University of Ferrara, Department of Experimental and Diagnostic Medicine, Section of General Pathology

2003-2006 Research Assistant running Telethon Center for Cellular Imaging, University of Ferrara

2006- Senior Postdoctoral Fellow ‘Post Vert’, Unité INSERM 807, Faculté de médecine Necker-Enfants Malades, University Paris V

Publications

Original Research Articles

Høyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, Elling F, Rizzuto R, Mathiasen IS, Jäättelä M. Control of macroautophagy by calcium, calmodulin dependent kinase kinase-ß and Bcl-2. Mol. Cell, 2007, in press

Szabadkai G, Bianchi K, Várnai P, De Stefani D, Wieckowski MR, Cavagna D, Nagy AI, Balla T, Rizzuto R. Chaperone mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels J. Cell Biol. 2006, in press

Poncet D, Pauleau AL, Szabadkai G, Vozza A, Scholz SR, Le Bras M, Brière JJ, Jalil A, Moigne RL, Brenner C, Hahn G, Wittig I, Schägger H, Lemaire C, Bianchi K, Souquère S, Pierron G, Rustin P, Goldmacher VS, Rizzuto R, Palmieri F, Kroemer G. Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA. J Cell Biol. 2006 25;174(7):985-96.

Wieckowski MR, Szabadkai G, Wasilewski M, Pinton P, Duszynski J, Rizzuto R. Overexpression of adenine nucleotide translocase reduces Ca2+ signal transmission between the ER and mitochondria. Biochem Biophys Res Commun. 2006; 348(2):393-399

K. Bianchi, G. Vandecasteele, C. Carli, A. Romagnoli, G. Szabadkai and R. Rizzuto. Regulation of Ca2+ signalling and Ca2+ mediated cell death by the transcriptional coactivator PGC-1α. Cell Death Differ., 2006;13(4):586-96.

Roumier T, Szabadkai G, Simoni AM, Perfettini JL, Paulau AL, Castedo M, Metivier D, Badley A, Rizzuto R, Kroemer G. HIV-1 protease inhibitors and cytomegalovirus vMIA induce mitochondrial fragmentation without triggering apoptosis. Cell Death Differ. 2006;13(2):348-51.

Gessi S, Varani K, Merighi S, Cattabriga E, Pancaldi C, Szabadkai G, Rizzuto R, Klotz KN, Leung E, Mac Lennan S, Baraldi PG and Borea PA. Expression, pharmacological profile and functional coupling of A2B receptors in a recombinant system and in peripheral blood cells by using a novel selective antagonist radioligand, [3H]-MRE 2029F20. Mol Pharmacol. 2005, 67(6):2137-47

M. Chami, A. Prandini, M. Campanella, P. Pinton, G. Szabadkai, J.C. Reed and R. Rizzuto Bcl-2 and Bax exert opposing effects on Ca2+ signalling, which do not depend on their putative pore-forming region. J. Biol. Chem., 2004, 279(52):54581-9

Szabadkai G., Simoni A.M., Wieckowski M.R., Chami M., Youle, R.J. and Rizzuto R. Drp-1 dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+ mediated apoptosis. Mol. Cell, 2004, 16, 59-68

Szabadkai G., Simoni A.M. and Rizzuto R. Mitochondrial Ca2+ Uptake Requires Sustained Ca2+ Release From The Endoplasmic Reticulum, J. Biol. Chem. 2003 25;278(17):15153-61

Rapizzi E., Pinton P., Szabadkai G., Wieckowski M.R., Vandecasteele G., Baird G., Tuft R.A., Fogarty K.E. and Rizzuto R. Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria J. Cell Biol.,159(4),2002, 613–624

Szabadkai G., Pitter J.G., Spät A. Cytoplasmic Ca2+ at low submicromolar concentration stimulates mitochondrial metabolism in rat luteal cells. Pflugers Archive, European Journal of Physiology 2001,441(5),678-685.

Szabadkai G., Várnai P. and Enyedi P. Ruthenium Red Selectively Antagonizes The Effects of Potassium on Rat Adrenal Glomerulosa Cells Biochem. Pharmacol. 1999,57,209-218

Horváth A., Szabadkai G., Spät A. and Enyedi P. Voltage Dependent Calcium Channels in Adrenal Glomerulosa Cells and in Insulin Producing Cells Cell Calcium 1998,23(1),33-42

Szabadkai G., Horváth A., Rohács T., Vimláti L., Spät A. and Enyedi P. Expression of inositol 1,4,5- trisphosphate receptors in rat adrenocortical zones Journal of Steroid Biochemistry and Molecular Biology 1996,57(1-2),13-17

Enyedi P., Szabadkai G., Horváth A., Szilágyi L., Gráf L. and Spät A. Inositol 1,4,5- Trisphosphate Receptors Subtypes in Adrenal Glomerulosa Cells Endocrinology 1994,134(6),2354-2359

Enyedi P., Szabadkai G., Krause K.H., Lew D.P. and Spät A. Inositol 1,4,5-trisphosphate binding sites copurify with the putative Ca-storage protein, calreticulin in rat liver. Cell Calcium 1993,14,485-492

Reviews

Szabadkai G, Simoni AM, Bianchi K, De Stefani D, Leo S, Wieckowski MR, Rizzuto R. Mitochondrial dynamics and Ca2+ signaling. Biochim Biophys Acta. 2006; 1763(5-6):442-9.

K. Bianchi, A. Rimessi, A. Prandini, G. Szabadkai and R. Rizzuto Calcium and mitochondria: mechanisms and functions of a troubled relationship. BBA Mol Cell Res, 2004, 1742(1-3):119-131.

Szabadkai G., Rizzuto R. Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighbourhood? FEBS Lett. 2004, 567(1):111-5.

Rizzuto R, Pinton P, Ferrari D, Chami M, Szabadkai G., Magalhaes PJ, Di Virgilio F, Pozzan T. Calcium and apoptosis: facts and hypotheses. Oncogene. 2003, 22(53):8619-27

Ferrari D, Pinton P, Szabadkai G, Chami M, Campanella M, Pozzan T, Rizzuto R. Endoplasmic reticulum, Bcl-2 and Ca(2+) handling in apoptosis. Cell Calcium 2002, 32(5-6):413-20.

Vandecasteele G., Szabadkai G. and Rizzuto R. Mitochondrial calcium homeostasis: mechanisms and molecules. IUBMB Life 2001, 52, 1-7

Spät A., Pitter J.G., Rohacs T. and Szabadkai G. Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells. News in Physiological Sciences, 2001,16,197-200.

Spät A., Pitter J., Rohacs T., Szabadkai G. Calcium signal and mitochondrial metabolism in steroid producing cells. Endocrine Research 2000, 26(4),615-616

Book Chapters

G. Szabadkai and R. Rizzuto. Mitochondrial-endoplasmic reticulum interactions. 2007 In: Handbook of Neurochemistry and Molecular Neurobiology, vol. 5: Neural Energy Utilization, Springer-Verlag, Eds.: Dienel G., Gibson G., 2006

G. Szabadkai and R. Rizzuto. Imaging Methods, 2004 In: Encyclopedia of Biological Chemistry, Elsevier, Eds.: Lennarz W.J., Lane M.D.

Szabadkai G., Chami M., Pinton P. and Rizzuto R. Modulation of Calcium Homeostasis by the Endoplasmic Reticulum in Health and Disease. 2002 In: Calreticulin, Landes Bioscience, Eds.:Eggleton P., Michalak M