Fludrocortisone

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Fludrocortisone has at least 50[1][2] times more mineralocorticoid activity than hydrocortisone.

Fludrocortisone one mg orally per day is equivalent to aldosterone 4 mg intramuscularly every six hours.[3]

References

  1. ↑ Goldfien A, Laidlaw JC, Haydar NA, Renold AE, Thorn GW (March 1955). "Fluorohydrocortisone and chlorohydrocortisone, highly potent derivatives of compound F". N. Engl. J. Med. 252 (11): 415–21. PMID 14356353. [e]
  2. ↑ Thorn GW, Renold AE, Morse WI, Goldfien A, Reddy WJ (November 1955). "Highly potent adrenal cortical steroids: structure and biologic activity". Ann. Intern. Med. 43 (5): 979–1000. PMID 13268992. [e]
  3. ↑ Thorn GW, Sheppard RH, Morse WI, Reddy WJ, Beigelman PM, Renold AE (May 1955). "Comparative action of aldosterone and 9-alpha-fluorohydrocortisone in man". Ann. N. Y. Acad. Sci. 61 (2): 609–19. PMID 13249284. [e]
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